525022

4-氨基吲哚

97%

• 同義詞: 4-吲哚胺
• 經驗公式（希爾表示法）: C₈H₈N₂
• CAS號碼: 5192-23-4
• 分子量：: 132.16
• Beilstein: 114919
• MDL號碼: MFCD01076559
• 分類程式碼代碼: 12352100
• PubChem物質ID: 24874461
• NACRES: NA.22

屬性

• 化驗: 97%
• mp: 106-109 °C (lit.)
• SMILES 字串: Nc1cccc2[nH]ccc12
• InChI: 1S/C8H8N2/c9-7-2-1-3-8-6(7)4-5-10-8/h1-5,10H,9H2
• InChI 密鑰: LUNUNJFSHKSXGQ-UHFFFAOYSA-N

描述

一般說明

4-Aminoindole is an indole derivative. Its cytokinin activity has been assessed by tobacco pith callus bioassay.[1] 4-Aminoindole can be prepared by reacting 2,6-dinitrotoluene and N,N-dimethylformamide dimethylacetal in anhydrous DMF.[2]

應用

4-Aminoindole may be used to synthesize:

• macrolactam tumour promoter indolactam V[3]
• tricyclic structure of 2-substituted-pyrrolo[2,3-h]quinolin-4-one[2]
• 4-azidoindole[4]

Reactant for preparation of:

• Inhibitors of bacterial thymidylate synthase
• Mimetics of non-alkaloid toxin lignan anticancer and antiviral agent Podophyllotoxin (PPT)
• Inhibitors of Gli1-mediated transcription in the Hedgehog pathway
• Protein kinase C θ (PKCθ) inhibitors
• Indolic non-peptidic HIV protease inhibitors
• Transient receptor potential cation channel subfamily V member 1 (TRPV1) antagonists
• Cyclooxygenase-2 (COX-2) and lipoxygenase (LOX) inhibitors
• 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) inhibitors
• Short chain 4-substituted indoles as potent αvβ3 antagonist
• Ligands of serotonin transporter and 5-HT1A receptors

安全資訊

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H315,H319,H335
• 防範說明: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• 危險分類: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 標靶器官: Respiratory system
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: dust mask type N95 (US), Eyeshields, Gloves