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361798

Sigma-Aldrich

二异丙基氨基锂 溶液

2.0 M in THF/heptane/ethylbenzene

同義詞:

LDA

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About This Item

線性公式:
[(CH3)2CH]2NLi
CAS號碼:
4111-54-0
分子量：:
107.12
Beilstein:
3655042
MDL號碼:
MFCD00064449
分類程式碼代碼:
12352001
PubChem物質ID:
24862259
NACRES:
NA.22
暫時無法取得訂價和供貨情況

形狀

liquid

品質等級

200

濃度

2.0 M in THF/heptane/ethylbenzene

雜質

3 wt. % diisopropylamine

密度

0.812 g/mL at 25 °C

官能基

amine

儲存溫度

2-8°C

SMILES 字串

[Li]N(C(C)C)C(C)C

InChI

1S/C6H14N.Li/c1-5(2)7-6(3)4;/h5-6H,1-4H3;/q-1;+1

InChI 密鑰

ZCSHNCUQKCANBX-UHFFFAOYSA-N

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相關類別

一般說明

二异丙基氨基锂溶液（LDA）是具空间位阻的非亲核性强碱，广泛用于有机合成。[1]

應用

二异丙基氨基锂溶液（LDA）可用于：
  • 用作引发剂，用于 D,L-丙交酯和甲基丙烯酸甲酯的阴离子催化聚合；[1]
  • 促进酯类烯醇化；[2]
  • 将羧酸转化为烯二醇中间物，制备三氟甲基酮；[3]
  • 芳基磺酰基恶唑烷酮的邻位锂化，制备N-取代糖精类似物；[4]
  • 催化芳基氨基甲酸酯的邻位锂化和弗莱斯（Fries）重排；[5]
  • 用作促进剂，促进烯丙基醚异构为（Z）-丙烯基醚。[6]

包裝

建议将25 mL Sure/Seal™ 瓶作为一次性瓶使用。 反复穿刺可能会导致产品性能下降。

法律資訊

Sure/Seal is a trademark of Sigma-Aldrich Co. LLC

訊號詞

Danger

危險分類

Aquatic Acute 1 - Aquatic Chronic 1 - Asp. Tox. 1 - Carc. 2 - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1B - STOT RE 2 - STOT SE 3

標靶器官

Central nervous system, hearing organs, Respiratory system

安全危害

EUH014,EUH019

儲存類別代碼

3 - Flammable liquids

水污染物質分類（WGK）

WGK 2

閃點（°F）

35.6 °F - closed cup

閃點（°C）

2 °C - closed cup

從最近期的版本中選擇一個：

分析證明 (COA)

Lot/Batch Number
SHBS5545
SHBR6949
STBL3831
STBL4766
STBL3550

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Questions

1–3 of 3 Questions  

  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  3. Hi, can I know if it's ok to store LDA in THF/heptane/ethylbenzene or in THF/hexane, and nBuLi in Hexanes at -20 degrees celsius? Thanks!

    1 answer

    1. The recommended storage temperature for this product is 2 - 8 °C.

      Helpful?

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