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Sigma-Aldrich

甲基-β-环糊精

average Mn 1310

同義詞:

MβCD, MEBCD, 甲基-β-CD, 甲基-β-环糊精

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About This Item

CAS號碼:
128446-36-6
MDL號碼:
MFCD00066764
分類程式碼代碼:
12352201
NACRES:
NA.22
暫時無法取得訂價和供貨情況

形狀

powder

品質等級

100

光學活性

[α]25/D +159°, c = 1 in H2O

分子量

average Mn 1310

標籤範圍

1.6-2.0 mol CH3 per unit anhydroglucose

顏色

white

mp

180-182 °C (lit.)

SMILES 字串

O1C2OC(C(OC3OC(C(OC4OC(C(OC5OC(C(OC6OC(C(OC7OC(C(OC8OC(C1C(C8OC)O)COC)C(C7OC)O)COC)C(C6OC)O)COC)C(C5OC)O)COC)C(C4OC)O)COC)C(C3OC)O)COC)C(C2OC)O)COC

InChI

1S/C56H98O35/c1-64-15-22-36-29(57)43(71-8)50(78-22)86-37-23(16-65-2)80-52(45(73-10)30(37)58)88-39-25(18-67-4)82-54(47(75-12)32(39)60)90-41-27(20-69-6)84-56(49(77-14)34(41)62)91-42-28(21-70-7)83-55(48(76-13)35(42)63)89-40-26(19-68-5)81-53(46(74-11)33(40)61)87-38-24(17-66-3)79-51(85-36)44(72-9)31(38)59/h22-63H,15-21H2,1-14H3

InChI 密鑰

QGKBSGBYSPTPKJ-UHFFFAOYSA-N

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相關類別

一般說明

甲基-β-环糊精(MβCD)是一种大环化合物，可以与许多客体分子形成包合物。与母体β-环糊精相比，它在水溶液中呈现更高的溶解度以及更强的增溶和络合能力。MβCD可用于增强有机溶剂中的酶活性和枯草酶的对映选择性。[1][2]

應用

甲基-β-环糊精可以用作：
  • 缓冲剂添加剂，通改良胶束电动毛细管色谱法（MEKC）结合激光诱导荧光检测有效分离氨基磷脂。[3]
  • 流动相添加剂，用于常规和纳米液相色谱法（nano-LC）分析商业片剂制剂中的R,S-萘普生混合物。[4]
  • 高效液相色谱法(HPLC)测定生物样品中分析物的分析标准品。[5]
  • 毛细管电泳法分离药物制剂中瑞格列奈对映异构体的手性选择剂。[6]

甲基-β-环糊精是一种除胆固醇剂[7] 主要用于破坏脂筏结构。[8]由于其对常用于膜蛋白化学的表面活性剂的高溶解度和亲和力，它还可以用于从蛋白质-脂质-表面活性剂三元混合物中去除表面活性剂以产生2D膜蛋白晶体。[8]

其他說明

为了全面了解我们针对客户研究提供的各种多糖产品，建议您访问我们的碳水化合物分类页面。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

368.6 °F

閃點（°C）

187 °C

個人防護裝備

Eyeshields, Gloves, type N95 (US)

從最近期的版本中選擇一個：

分析證明 (COA)

Lot/Batch Number
STBL4111
STBL1244
STBK8343
STBK7715
STBH9769

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存取文件庫

Controlled 2D crystallization of membrane proteins using methyl-?-cyclodextrin.
Signorell GA, et al.
Journal of Structural Biology, 157(2), 321-328 (2007)
P Y Grosse et al.
Journal of chromatography. B, Biomedical sciences and applications, 694(1), 219-226 (1997-06-20)
This paper describes a high-performance liquid chromatographic method with fluorescence detection for the analysis of methyl-beta-cyclodextrin (MEBCD) in plasma and cell lysate, after in situ complexation with 1-naphthol. The size-exclusion HPLC column packed with TSK 3000 SW gel, was equilibrated
Le Zhang et al.
Electrophoresis, 23(17), 3071-3077 (2002-09-11)
Micellar electrokinetic capillary chromatography (MEKC) with laser-induced fluorescence detection is used for the analysis of three classes of aminophospholipids: phosphatidylethanolamine (PE), phosphatidylserine (PS), and lysophosphatidylethanolamine (LPE) molecular species. 3-(2-Furoyl) quinoline-2-carboxaldehyde (FQ), a fluorogenic dye, was employed for labeling of these
L O Healy et al.
Journal of chromatography. A, 924(1-2), 459-464 (2001-08-28)
Chiral separations of R,S-naproxen mixtures were obtained on an achiral column (ODS) with methyl-beta-cyclodextrin as a mobile phase additive using conventional and nano-LC. The optimised mobile phase composition was 20 mmol l(-1) methyl-beta-cyclodextrin, 20% (v/v) acetonitrile, and 50 mmol l(-1)
Andreza Ribeiro et al.
AAPS PharmSciTech, 9(4), 1102-1109 (2008-11-01)
The aim of this study is to confirm the formation of inclusion complexes between miconazole (MCZ) and two derivatives of beta-cyclodextrin, methyl-beta-cyclodextrin (MbetaCD) and 2-hydroxypropyl-beta-cyclodextrin (HPbetaCD) in aqueous solution by phase solubility studies. Inclusion complexes with MbetaCD in the solid
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  1. How is shipping temperature determined? And how is it related to the product storage temperature?

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    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

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    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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