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重要文件

328464

Sigma-Aldrich

2-氮杂环丁酮

98%

同義詞:

β-丙内酰胺, 氮杂环丁酮

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About This Item

經驗公式(希爾表示法):
C3H5NO
CAS號碼:
分子量::
71.08
Beilstein:
104563
MDL號碼:
分類程式碼代碼:
12352100
PubChem物質ID:
NACRES:
NA.22
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化驗

98%

bp

106 °C/15 mmHg (lit.)

mp

74-76 °C (lit.)

溶解度

chloroform: very soluble(lit.)
ethanol: very slightly soluble(lit.)
water: very soluble(lit.)

儲存溫度

2-8°C

SMILES 字串

O=C1CCN1

InChI

1S/C3H5NO/c5-3-1-2-4-3/h1-2H2,(H,4,5)

InChI 密鑰

MNFORVFSTILPAW-UHFFFAOYSA-N

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一般說明

2-Azetidinone is an unsubstituted four membered lactam.[1] 2-Azetidinone is the fundamental building block of β-lactam antibiotics.[2] X-ray photoelectron spectra of 2-azetidinone was investigated.[2] 2-Azetidinone undergoes hydrolysis with aqueous alkali to yield β-alanine.[1]

應用

2-Azetidinone was used in synthesis of optically pure densely functionalized γ-lactams.[3]

象形圖

Corrosion

訊號詞

Danger

危險聲明

危險分類

Skin Corr. 1B

儲存類別代碼

8A - Combustible corrosive hazardous materials

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges


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2-Azetidinone (?-propiolactam)
Holley RW and Holley AD.
Journal of the American Chemical Society, 71(6), 2129-2131 (1949)
Benito Alcaide et al.
The Journal of organic chemistry, 69(3), 993-996 (2004-01-31)
A synthesis of optically pure densely functionalized gamma-lactams starting from 2-azetidinone-tethered iminophosphoranes has been developed. Full chirality transfer has been accomplished from the enantiomerically pure 2-azetidinones. The addition of lithium acetylides to 4-oxoazetidine-2-carbaldehydes at -78 degrees C smoothly yielded propargylic
Investigation of the molecular structure and VUV-induced ion dissociation dynamics of 2-azetidinone (C3 H5 NO).
Alexsandre F Lago et al.
Rapid communications in mass spectrometry : RCM, 35(3), e8988-e8988 (2020-10-24)
Marawan Ahmed et al.
The journal of physical chemistry. A, 116(33), 8653-8660 (2012-07-18)
X-ray photoelectron spectra of the core and valence levels of the fundamental building blocks of β-lactam antibiotics have been investigated and compared with theoretical calculations. The spectra of the compounds 2-azetidinone and the 2- and 4-isomers of thiazolidine-carboxylic acid are
Tim N Beck et al.
Bioorganic & medicinal chemistry, 23(3), 632-647 (2015-01-01)
The prevalence of drug resistance in both clinical and community settings as a consequence of alterations of biosynthetic pathways, enzymes or cell wall architecture is a persistent threat to human health. We have designed, synthesized, and tested a novel class

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