27370

辛可宁

crystallized, ≥98.0% (NT)

• 同義詞: NSC 6176
• 經驗公式（希爾表示法）: C₁₉H₂₂N₂O
• CAS號碼: 118-10-5
• 分子量：: 294.39
• Beilstein: 89689
• EC號碼: 204-234-6
• MDL號碼: MFCD00064372
• 分類程式碼代碼: 12352104
• PubChem物質ID: 57648242
• NACRES: NA.22

屬性

• 品質等級: 100
• 化驗: ≥98.0% (NT)
• 形狀: powder
• 光學活性: [α]20/D +225±5°, c = 0.5% in ethanol
• 品質: crystallized
• 雜質: ~15% dihydrocinchonine (HPLC)
• mp: 260-263 °C
• 官能基: hydroxyl
• SMILES 字串: O[C@H]([C@H]1C[C@@H]2CCN1C[C@@H]2C=C)c3ccnc4ccccc34
• InChI: 1S/C19H22N2O/c1-2-13-12-21-10-8-14(13)11-18(21)19(22)16-7-9-20-17-6-4-3-5-15(16)17/h2-7,9,13-14,18-19,22H,1,8,10-12H2/t13-,14-,18+,19-/m0/s1
• InChI 密鑰: KMPWYEUPVWOPIM-QAMTZSDWSA-N
• 基因資訊: human ... CYP2D6(1565)

描述

一般說明

Cinchonine is a cinchona alkaloid generally found in the bark of Cinchona officinalis plants. It is a pseudoenantiomer that is commonly employed in malaria therapy.[1] Cinchonine is also used as an organocatalyst in many asymmetric reactions.[2][3]

應用

Cinchonine can be used:

• As a substrate in the study of supercritical fluid chromatography (SFC) parameters in pharmaceutical analysis.[4]
• To prepare possible butyrylcholinesterase inhibitors.[5]

安全資訊

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H302,H317
• 防範說明: P261 - P264 - P272 - P280 - P301 + P312 - P302 + P352
• 危險分類: Acute Tox. 4 Oral - Skin Sens. 1A
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 1
• 個人防護裝備: dust mask type N95 (US), Eyeshields, Gloves