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138630

Sigma-Aldrich

1-氯-2,4-二硝基苯

97%

同義詞:

2,4-二硝基氯苯, CDNB, DNCB

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About This Item

線性公式:
ClC6H3(NO2)2
CAS號碼:
97-00-7
分子量：:
202.55
Beilstein:
613161
EC號碼:
202-551-4
MDL號碼:
MFCD00007075
分類程式碼代碼:
12352100
PubChem物質ID:
24848362
NACRES:
NA.22
暫時無法取得訂價和供貨情況

品質等級

100

化驗

97%

形狀

solid

expl. lim.

22 %

bp

315 °C (lit.)

mp

48-50 °C (lit.)

溶解度

alcohol: soluble (hot)
alcohol: very slightly soluble (cold)
benzene: soluble
carbon disulfide: soluble
diethyl ether: soluble
water: insoluble

官能基

chloro
nitro

SMILES 字串

[O-][N+](=O)c1ccc(Cl)c(c1)[N+]([O-])=O

InChI

1S/C6H3ClN2O4/c7-5-2-1-4(8(10)11)3-6(5)9(12)13/h1-3H

InChI 密鑰

VYZAHLCBVHPDDF-UHFFFAOYSA-N

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相關類別

應用

1-氯代-2,4-二硝基苯用于逆相HPLC检测人体组织中单个谷胱甘肽S转移酶亚基相对含量。[1]它可作为接触敏化剂，研究抗菌肽链hBD-2,-3和-4以及LL-37诱导的人角质细胞 IL-18蛋白质释放。[2]

生化／生理作用

2,4-二硝基氯代笨诱发BALB/c小鼠模型特应性皮炎。[3]

準備報告

当作为谷胱甘肽S转移酶底物时，将该产品溶于乙醇，然后加入缓冲溶液，形成终浓度为1mM的磷酸盐缓冲液 (8 mL 0.2M KH2PO4和28ml 0.1M Na2HPO4每100ml溶液，调节到pH6.5）4%(v/v)乙醇。

訊號詞

Danger

危險分類

Acute Tox. 2 Dermal - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Irrit. 2 - Skin Sens. 1

儲存類別代碼

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

水污染物質分類（WGK）

WGK 2

閃點（°F）

381.2 °F - closed cup

閃點（°C）

194 °C - closed cup

個人防護裝備

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

從最近期的版本中選擇一個：

分析證明 (COA)

Lot/Batch Number
STBL1466
STBK6718
STBK3781
STBK3548
STBK2336

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2,4-二硝基氟苯 purum p.a., ≥98.0% (GC)

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Sigma-Aldrich

102369

对二硝基苯

J D Rowe et al.
The Biochemical journal, 325 ( Pt 2), 481-486 (1997-07-15)
Uncertainties about the composition and identities of glutathione S-transferases (GSTs) in human tissue have impeded studies on their biological functions. A rigorous protocol has therefore been developed to characterize the human proteins. Cytosolic GST subunits were resolved by reverse-phase HPLC
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Journal of immunology (Baltimore, Md. : 1950), 175(3), 1776-1784 (2005-07-22)
In addition to its physical barrier against invading microorganisms, the skin produces antimicrobial peptides, human beta-defensins (hBDs) and cathelicidin LL-37, that participate in the innate host defense. Because IL-18 is produced by keratinocytes and involved in skin diseases in which
Mingli Sun et al.
Molecular medicine reports, 9(2), 689-694 (2013-12-18)
Bacillus Calmette-Guerin extract (BCGE) has been proven to be clinically effective for anaphylactic disease, infectious diseases and cancer. In this study, we investigated the effect of the intramuscular application of BCGE on 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD). We established an
Antony Anet et al.
Journal of hazardous materials, 370, 42-53 (2018-09-15)
This study investigates Bisphenol A (BPA) induced oxidative stress that mediates the genotoxicity in in vivo model Drosophila melanogaster. The calculated LC50 for BPA was 12.35 μg/mL. The strains of D. melanogaster were reared in 0.1, 1.0, 2.5 and 5.0 μg/mL BPA
L S Tran et al.
The Journal of investigative dermatology, 134(9), 2438-2446 (2014-04-16)
We have shown that the expression of human papillomavirus type 16 E7 (HPV16.E7) protein within epithelial cells results in local immune suppression and a weak and ineffective immune response to E7 similar to that occuring in HPV-associated premalignancy and cancers.
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  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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