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T7254

Sigma-Aldrich

Nα-甲苯磺酰基- L -赖氨酸氯甲基酮 盐酸盐

powder, ≥96% (TLC)

同義詞:

(3S)-1-氯-3-甲苯磺酰氨基-7-氨基-2-庚酮 盐酸盐, (3S)-7-氨基-1-氯-3-甲苯磺酰氨基-2-庚酮 盐酸盐, TLCK, 甲苯磺酰基- L -赖氨酰-氯甲烷 盐酸盐

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About This Item

經驗公式（希爾表示法）:
C14H21ClN2O3S · HCl
CAS號碼:
4272-74-6
分子量：:
369.31
Beilstein:
7106867
EC號碼:
224-266-4
MDL號碼:
MFCD00065395
分類程式碼代碼:
12352202
PubChem物質ID:
24278752
NACRES:
NA.77

product name

Nα-甲苯磺酰基- L -赖氨酸氯甲基酮 盐酸盐, ≥96% (TLC), powder

生物源

synthetic (organic)

品質等級

200

化驗

≥96% (TLC)

形狀

powder

效力

10-100 μM effective concentration

溶解度

H2O: 50 mg/mL

儲存溫度

−20°C

SMILES 字串

Cl[H].Cc1ccc(cc1)S(=O)(=O)N[C@@H](CCCCN)C(=O)CCl

InChI

1S/C14H21ClN2O3S.ClH/c1-11-5-7-12(8-6-11)21(19,20)17-13(14(18)10-15)4-2-3-9-16;/h5-8,13,17H,2-4,9-10,16H2,1H3;1H/t13-;/m0./s1

InChI 密鑰

YFCUZWYIPBUQBD-ZOWNYOTGSA-N

基因資訊

human ... NFKB1(4790) , NFKB2(4791)

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應用

Nα-对甲苯磺酰-L-赖氨酸氯甲基酮盐酸盐已用于：
  • 在胰凝乳蛋白酶纯化中抑制粗提液中的胰蛋白酶，从而防止其与亲和载体结合
  • 作为组织和细胞匀浆的蛋白酶抑制剂
  • 作为胰蛋白酶抑制剂测定特定蛋白酶的活性水平

生化／生理作用

Nα-对甲苯磺酰-L-赖氨酸氯甲基酮盐酸盐(TLCK)抑制脂多糖(LPS)或细胞因子诱导的核因子κB (NF-κB)活化，从而抑制诱导型一氧化氮合酶(iNOS)和环氧合酶(COX-2)的转录激活。它可抑制所有有丝分裂原诱导的pp70s6k激活。还可通过抑制某些细胞株中和刺激下发生的胱天蛋白酶过程而抑制细胞株凋亡。

包裝

无底玻璃瓶。内含物在插入的融合锥内。

注意

20°C 干燥条件下储存时至少可稳定两年。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves

分析證明 (COA)

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