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Merck
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文件

C247

Sigma-Aldrich

Cyclazosin hydrochloride

solid

同義詞:

1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl) decahydroquinoxaline

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About This Item

經驗公式（希爾表示法）:
C23H27N5O4 · HCl
CAS號碼:
146929-33-1
分子量：:
473.95
MDL號碼:
MFCD01860867
分類程式碼代碼:
12352202
PubChem物質ID:
24892491
NACRES:
NA.77

形狀

solid

顏色

white

溶解度

H2O: 1.8 mg/mL
methanol: 14 mg/mL
DMSO: 2.5 mg/mL

SMILES 字串

Cl.COc1cc2nc(nc(N)c2cc1OC)N3CCN(C4CCCCC34)C(=O)c5ccco5

InChI

1S/C23H27N5O4.ClH/c1-30-19-12-14-15(13-20(19)31-2)25-23(26-21(14)24)28-10-9-27(16-6-3-4-7-17(16)28)22(29)18-8-5-11-32-18;/h5,8,11-13,16-17H,3-4,6-7,9-10H2,1-2H3,(H2,24,25,26);1H

InChI 密鑰

SKDIDWRQDBIQBS-UHFFFAOYSA-N

生化／生理作用

α1B-adrenoceptor antagonist.

特點和優勢

This compound is featured on the α1-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

分析證明 (COA)

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D Giardinà et al.
European journal of pharmacology, 287(1), 13-16 (1995-12-04)
The binding profile of cyclazosin, a new prazosin-related alpha 1-adrenoceptor antagonist, at alpha 1-, alpha 2-adrenoceptors, dopamine D2 and 5-HT1A receptors was compared to that of 5-methylurapidil, spiperone, risperidone and other prazosin-related ligands. In addition, cyclazosin was investigated at native
Hadeel A Alsufyani et al.
Pharmacological reports : PR, 73(1), 255-260 (2020-08-30)
The spleen is a reservoir for circulating blood cells, and can contract to expel them. We have investigated the adrenoceptors involved in isometric contractions of rat spleen produced by noradrenaline (NA) and the α1-adrenoceptor agonist phenylephrine (Phe). Contractions to NA
D Giardinà et al.
Journal of medicinal chemistry, 39(23), 4602-4607 (1996-11-08)
The enantiomers of [4-(4-amino-6, 7-dimethoxyquinazolin-2-yl)-cis-octahydroquinoxalin-1-yl]-fu ran- 2-ylmethanone (cyclazosin, 1) were synthesized from the chiral furan-2-yl(cis-octahydroquinoxalin-1-yl)methanone [(+)-2 and (-)-2], which were obtained by resolution of the racemic amine with (S)-(+)- and (R)-(-)-mandelic acid. The binding profile of the enantiomers of 1

文章

α1-Adrenoceptor Characteristics and Modulators

Review alpha 1 adrenoceptors as well as their agonists, antagonists, and tissue expression patterns. We suggest several modulators and alternatives for working with a-1 adrenoreceptors.

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