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Merck
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重要文件

T3068

Sigma-Aldrich

凝血酶产生显色底物

≥90% (HPLC), solid

同義詞:

β-Ala-Gly-Arg-p-硝基苯胺二乙酸酯

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About This Item

經驗公式(希爾表示法):
C21H34N8O9
分子量::
542.54
MDL號碼:
分類程式碼代碼:
12352204
NACRES:
NA.32

生物源

synthetic (organic)

品質等級

化驗

≥90% (HPLC)

形狀

solid

技術

activity assay: suitable

儲存溫度

2-8°C

SMILES 字串

[N+](=O)([O-])c1ccc(cc1)NC(=O)[C@@H](NC(=O)CNC(=O)CCN)CCCNC(=N)N.OC(=O)C.OC(=O)C

InChI 密鑰

PBMJNSQKWBTVOL-GXKRWWSZSA-N

Amino Acid Sequence

Ala-Gly-Arg-pNA

應用

凝血酶产生的显色底物可用于通过适体亲和捕获而产生的显色检测,并通过随后的酶反应用于检测稀释的人血清中的凝血酶。

生化/生理作用

凝血酶产生的显色底物也被称为β-Ala-Gly-Arg对硝基苯胺,可被人凝血酶蛋白水解切割并产生β-Ala-Gly-Arg和对硝基苯胺。 对硝基苯胺的释放进行定量后可评估抗凝血酶的活性。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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條款

Thrombin is an endolytic serine protease that selectively cleaves the Arg–Gly bonds of fibrinogen to form fibrin and release fibrinopeptides A and B.

凝血酶是一種內溶性絲氨酸蛋白酶,可選擇性地裂解纖維蛋白原的 Arg-Gly 鍵,形成纖維蛋白並釋放出纖維蛋白肽 A 和 B。

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