T7154

Tyr-Ile-Gly-Ser-Arg

≥97% (HPLC)

• Synonym(s): Laminin Fragment 929-933
• Empirical Formula (Hill Notation): C₂₆H₄₂N₈O₈
• CAS Number: 110590-64-2
• Molecular Weight: 594.66
• NACRES: NA.32
• PubChem Substance ID: 24900419
• UNSPSC Code: 12352209
• MDL number: MFCD00076472
• Form: powder
• Assay: ≥97% (HPLC)
• Biological source: synthetic (organic)

Properties

• biological source: synthetic (organic)
• Quality Level: 200
• assay: ≥97% (HPLC)
• form: powder
• technique(s): cell culture | mammalian: suitable
• solubility: H₂O: soluble 1 mg/mL, clear, colorless
• storage temp.: −20°C
• SMILES string: CC[C@H](C)[C@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O
• InChI: 1S/C26H42N8O8/c1-3-14(2)21(34-22(38)17(27)11-15-6-8-16(36)9-7-15)24(40)31-12-20(37)32-19(13-35)23(39)33-18(25(41)42)5-4-10-30-26(28)29/h6-9,14,17-19,21,35-36H,3-5,10-13,27H2,1-2H3,(H,31,40)(H,32,37)(H,33,39)(H,34,38)(H,41,42)(H4,28,29,30)/t14-,17-,18-,19-,21-/m0/s1
• InChI key: MWOGMBZGFFZBMK-LJZWMIMPSA-N

Description

Application

Tyr-Ile-Gly-Ser-Arg (YIGSR) can be used at the interface between the conjugated polymer and the tissue for the engineering of tissue interface. The product can also be used to study the role of integrins β1, α6, and α3 in promoting type II epithelial differentiation during lung maturation in the fetus.[1]

Biochem/physiol Actions

Tyr-Ile-Gly-Ser-Arg (YIGSR) is a pentapeptide of the protein laminin that reduces the lung colony formation in mice administered with melanoma cells as well as can block the invasiveness of the cells in vitro.[2] It inhibits the increased expression of endothelial nitric-oxide synthase in primary porcine aortic endothelial cells.[3]

Tyr-Ile-Gly-Ser-Arg is a fragment of domain III of the laminin B1 chain . It is a major receptor binding site in laminin. It competes with laminin for the cell surface receptor. It is an inhibitor of tumor growth and metastasis.

Preparation Note

Tyr-Ile-Gly-Ser-Arg dissolves in water at 1 mg/ml to yield a clear, colorless solution.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)