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Organoaluminum Reagents

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Chemical structure of aluminum triisobutyl, depicted as an aluminum atom bonded to three isobutyl groups (CH3)2CHCH2.
Chemical structure of aluminum tri-n-hexyl, showing an aluminum atom centrally bonded to three n-hexyl groups, each consisting of a linear chain of six carbon atoms ending with a methyl group.
A chemical structure diagram featuring three benzene rings connected to a central atom labeled "AI".

Organoaluminum reagents are powerful tools for organic synthesis and the development of new technologies and play an important role in the formation of known bond formations. 

Selection of applications: 

  • Some organoaluminum reagents react with carbonyl compounds to afford the corresponding allenic alcohols or homopropargylic alcohols.
  • Organoaluminum reagents can participate in copper-catalyzed kinetic resolution of alkenyl cyclopropane malonates.
  • Cationic organoaluminum compounds are potential hydroamination catalysts.
  • Organoaluminum reagents are also employed in asymmetric conjugate addition reactions due to their commercial availability and proof of application in carboalumination reactions.

Since several organoaluminum reagents display high sensitivity to both air and moisture, we provide top-quality packaging in Sure/Seal™ bottles to prolong the lifetime of these reagents. Smaller-sized bottles require fewer needle entries to consume the reagent volume. Therefore, many of our organometallic reagents are also being transitioned into exclusive 25 mL Sure/Seal™ packaging to reduce waste and decomposition of more unstable reagents.

Discover how our organoaluminum reagents can enable your cross-coupling reactions and facilitate the discovery of new bond-forming methodologies. We also offer organozinc reagents and organosilicon reagents for all your organometallic applications.

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Related Applications
C–H Functionalization
C–H functionalization is the reliable and predictable conversion of a C–H into a C–C, C–N, C–O, or C–X bond in a selective and controlled fashion.
Cross-Coupling
Cross-coupling is a common reaction in organic chemistry for the creation of C-C, C-N, and C-O bonds with the aid of a metal catalyst.
Fluorination
Fluorination is the introduction of fluorine to a compound via electrophilic fluorination, nucleophilic fluorination, difluoromethylation, trifluoromethylation, or perfluoroalkylation.
Metathesis
Olefin metathesis involves an organic reaction that redistributes fragments of alkenes (olefins) by cleavage and transformation of carbon-carbon double bonds.
Photocatalysis
Photoredox catalysis uses visible light and photocatalysts for synthetic transformations like cross-coupling and functionalization reactions.
Organic Reaction Toolbox
An organic reaction toolbox provides structure-activity relationships for unique chemical reactions to optimally design and control small molecule synthesis.
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