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mAbs Characterization & Quality Control

The key for ensuring drug safety and efficacy

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Characterization and quality control of monoclonal antibodies (mAbs) is essential to ensure their efficacy and safety. Analytical techniques, like HPLC and mass spectrometry, are vital to assess various properties, such as aggregation, charge variants, and post-translational modifications (PTMs). Our extensive selection of products supports the detailed analysis and evaluation of mAbs to maintain quality and effectiveness.

Characterization and Quality Control
Intact Mass Analysis
Peptide Mapping
Post-Translational Modification Analysis
Aggregate Analysis
Titer Determination
Microbiological Testing

Intact Mass Analysis of Monoclonal Antibodies

Intact mass analysis of monoclonal antibodies is performed to determine accurate molecular weights of mAb proteoforms for characterization and quality control of the mAb. This technique analyzes mAbs in their intact state using high-resolution mass spectrometry to confirm amino acid composition and detect heterogeneities and glycoforms.​

Discover our wide variety of products to monitor the quality and verify consistency in your mAb workflow, including high-performance size-exclusion columns (SEC), ion exchange columns, reversed-phase columns, HPLC buffers, MALDI matrices and standards, high-purity solvents, reagents, tools for protein sample preparation, and reference materials. 

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HPLC Columns

Achieve precise separations and characterization with our SEC, ion exchange, and RP columns.

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HPLC Buffers

Reliably couple your analysis directly to the MS with our MS-compatible buffers.

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High-Purity Solvents

Use our highest grade of solvents in mAb production to minimize the risk of impurities.

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MALDI Matrices and Standards

Analyze critical information on the identity, purity, and structural integrity of mAbs.

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Analytical Reagents

Explore our ELISA kits, Western blotting reagents, and fluorescent dyes for mAb characterization.

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Protein Sample Preparation

Ensure the accuracy and reliability of downstream analytical techniques by isolating the mAb.

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Reference Materials

Use for calibrating and validating analytical methods to ensure high purity and accuracy.

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Related Webinars

Tips & Tricks to Improve MS Sensitivity

Learn how to enable and maintain high quality and high sensitivity in LC-MS analyses by preventing impurities and contaminations.

Improving Bioanalysis Workflows

Explore a simple and high throughput method for the quantitation of monoclonal antibodies and proteins in human and animal serum.

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Characterization & Quality Control
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