This product is tested for solubility at 5 mg in 0.1 mL of water. The stock solution should be stored at -80 °C and used within 6 months. When stored at -20 °C, it should be used within 1 month.
P9716
Palmitoyl coenzyme A lithium salt
≥90%, 3-ketodihydrosphingosine precursor, powder
Synonym(s):
n-Hexadecanoyl Coenzyme A, Hexadecanoyl coenzyme A
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About This Item
Empirical Formula (Hill Notation):
C37H65N7O17P3S · xLi+
CAS Number:
Molecular Weight:
1004.94 (free acid basis)
UNSPSC Code:
51111800
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Pricing and availability is not currently available.
Product Name
Palmitoyl coenzyme A lithium salt, ≥90%
Quality Level
assay
≥90%
form
powder
storage temp.
−20°C
SMILES string
[Li+].CCCCCCCCCCCCCCCC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)([O-])=O)n2cnc3c(N)ncnc23
InChI
1S/C37H66N7O17P3S.Li/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44;/h24-26,30-32,36,47-48H,4-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52);/q;+1/p-1/t26-,30-,31-,32+,36-;/m1./s1
InChI key
BSAYABVAJQBKKB-NNGKVBCISA-M
Application
Palmitoyl coenzyme A lithium salt has been used for microinjecting newt egg, to study the effect of citrate synthase inhibition in egg activation. It has also been used in reaction mix for thioesterase I (tesA) enzymatic activity assay.Palmitoyl coenzyme A lithium salt has been used in in vitro S-palmitoylation of cyclophilin D.[1]
Biochem/physiol Actions
Palmitoyl coenzyme A (CoA) is an acyl-CoA and a precursor of 3-ketodihydrosphingosine, a key element of sphingoid base backbone[2] during the De novo sphingolipid biosynthesis. Palmitoyl CoA is a long chain fatty acid (C16) covalently linked to Coenzyme A. Covalent attachment of palmitate is a common occurrence on a wide variety of viral and cellular proteins and plays a role in promoting membrane binding. Palmitoylation may also be a general mechanism for prolonging or potentiating G-protein signaling.
Palmitoyl coenzyme A is useful in the biosynthesis of sphingosine, a component of sphingolipids and phospholipids.β-Oxidation of Palmitoyl-CoA yields 8 acetyl-CoA molecules and 14 pairs of hydrogen atoms.
Features and Benefits
This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
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This Item | |||
|---|---|---|---|
| form powder | form powder | form - | form - |
| assay ≥90% | assay ~90% | assay ≥80.0% | assay ≥90% |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Articles
Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
Diel light: dark cycles significantly reduce FFA accumulation in FFA producing mutants of Synechocystis sp. PCC 6803 compared to continuous light
Cheah YE, et al.
Algal research, 12, 487-496 (2015)
Biochemistry: The Chemical Reactions of Living Cells, 992-992 (2001)
Velayoudame Parthibane et al.
The Journal of biological chemistry, 296, 100491-100491 (2021-03-05)
Serine palmitoyltransferase complex (SPT) mediates the first and rate-limiting step in the de novo sphingolipid biosynthetic pathway. The larger subunits SPTLC1 and SPTLC2/SPTLC3 together form the catalytic core while a smaller third subunit either SSSPTA or SSSPTB has been shown
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What concentration do you recommend we dissolve it in? And when you replied "The product should be used within 6 months when stored at -80°C/ within a month after being stored at -20°C." Was that in its salt form or aqeuous form? Water or methanol?
1 answer-
Helpful?
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What is the Li content? Is Li content 2 mol/mol.
1 answer-
The lithium content for this product is batch-dependent and ranges from 0.5 to 1.8 percent. The amount of lithium is found in the Certificate of Analysis.
Helpful?
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What is the stability in aqueous solution at -20 or -80?
1 answer-
The product should be used within 6 months when stored at -80°C. The product should be used within a month after being stored at -20°C.
Helpful?
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