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Phleomycin

Name: Phleomycin
Brand: SIGMA

from Streptomyces verticillus, powder, DNA replication inhibitor

Synonym(s):

FT-0697305

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About This Item

CAS Number:

11006-33-0

UNSPSC Code:

12352200

NACRES:

NA.77

MDL number:

MFCD00131846

Form:

powder

Quality level:

200

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Properties

Product Name

Phleomycin from Streptomyces verticillus, powder

form

powder

Quality Level

200

shelf life

2 yr

color

blue

antibiotic activity spectrum

fungi

mode of action

DNA synthesis | interferes

storage temp.

2-8°C

InChI

1S/C51H75N17O21S2/c1-16-29(65-41(68-38(16)54)21(8-27(53)72)60-9-20(52)39(55)78)44(82)67-31(34(22-10-58-15-61-22)88-49-50(5,36(76)33(74)25(11-69)87-49)89-47-37(77)51(85,48(57)84)35(75)26(12-70)86-47)45(83)62-18(3)32(73)17(2)42(80)66-30(19(4)71)43(81)59-7-6-28-63-24(14-90-28)46-64-23(13-91-46)40(56)79/h10,13,15,17-18,20-21,24-26,30-37,47,49,60,69-70,73-77,85H,6-9,11-12,14,52H2,1-5H3,(H2,53,72)(H2,55,78)(H2,56,79)(H2,57,84)(H,58,61)(H,59,81)(H,62,83)(H,66,80)(H,67,82)(H2,54,65,68)/t17?,18?,20?,21?,24?,25-,26?,30?,31?,32?,33+,34?,35-,36-,37-,47-,49-,50-,51+/m0/s1

InChI key

QRBLKGHRWFGINE-UGWAGOLRSA-N

Description

General description

Phleomycin is a glycopeptide antibiotic and is a member of the bleomycin family.[1]

Application

Phleomycin from Streptomyces verticillus has been used as an antibiotic in the screening of transformants of Trypanosoma brucei[2]. It has also been used as an antibiotic in the maintenance of Escherichia coli.[3]

Biochem/physiol Actions

Phleomycin can bind and intercalate with the DNA that leads to DNA strand breaks. It acts as an inhibitor of DNA replication.[1]

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

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Show Differences

1 of 1

This Item	B5507	15361	5711
Sigma-Aldrich P9564 Phleomycin from Streptomyces verticillus	Sigma-Aldrich B5507 Bleomycin sulfate from Streptomyces verticillus	Sigma-Aldrich 15361 Bleomycin sulfate from Streptomyces verticillus	Sigma-Aldrich 5711 Streptomycin Sulfate, Streptomyces sp.
form powder	form crystalline	form powder or crystals	form powder
Quality Level 200	Quality Level 200	Quality Level 200	Quality Level 100
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C
color blue	color white to off-white	color white to off-white	color white to off-white
mode of action DNA synthesis \| interferes	mode of action DNA synthesis \| interferes	mode of action DNA synthesis \| interferes	mode of action -
shelf life 2 yr	shelf life -	shelf life -	shelf life -

pictograms

GHS07

signalword

Warning

hcodes

H302

pcodes

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number

0000543050

0000462297

0000462296

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Articles

Discover Bioactive Small Molecules for Cell Cycle

Cell cycle phases (G1, S, G2, M) regulate cell growth, DNA replication, and division in proliferating cells.

Bioactive Molecules for Apoptosis

Apoptosis regulation involves multiple pathways and molecules for cellular homeostasis.

Copper(II).bleomycin, iron(III).bleomycin, and copper(II).phleomycin: comparative study of deoxyribonucleic acid binding.

L F Povirk et al.

Biochemistry, 20(3), 665-671 (1981-02-03)

The kinetics and mechanism of binding of Cu-(II).bleomycin, Fe(III).bleomycin, and Cu(II).phleomycin to DNA were studied by using fluorometry, equilibrium dialysis, electric dichroism, and temperature-jump and stopped-flow spectrophotometry. The affinity of Cu(II).bleomycin for DNA was greater than that of metal-free bleomycin

Analysis of gene function in Trypanosoma brucei using RNA interference.

Appolinaire Djikeng et al.

Methods in molecular biology (Clifton, N.J.), 265, 73-83 (2004-04-23)

Trypanosoma brucei, a flagellate protozoa of the family Trypanosomatidae, has become one of the model systems for unicellular pathogens to study fundamentally important biological phenomena. Currently, the method of choice to examine gene function in these organisms is RNA interference

A Saccharomyces cerevisiae phleomycin-sensitive mutant, ph140, is defective in the RAD6 DNA repair gene.

C H He et al.

Canadian journal of microbiology, 42(12), 1263-1266 (1996-12-01)

The antibiotic bleomycin is used as an anticancer agent for treating a variety of tumours. The antitumour effect of bleomycin is related to its ability to produce lesions such as apurinic/apyrimidinic sites and single- and double-strand breaks in the cellular