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P2149

Physalaemin

≥97% (HPLC)

Synonym(s):

pGlu-Ala-Asp-Pro-Asn-Lys-Phe-Tyr-Gly-Leu-Met-NH2

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About This Item

Empirical Formula (Hill Notation):
C58H84N14O16S
CAS Number:
2507-24-6
Molecular Weight:
1265.44
UNSPSC Code:
12352200
PubChem Substance ID:
24898279
MDL number:
MFCD00076375
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assay

≥97% (HPLC)

UniProt accession no.

P01308

storage temp.

−20°C

SMILES string

CSCCC(NC(=O)C(CC(C)C)NC(=O)CNC(=O)C(Cc1ccc(O)cc1)NC(=O)C(Cc2ccccc2)NC(=O)C(CCCCN)NC(=O)C(CC(N)=O)NC(=O)C3CCCN3C(=O)C(CC(O)=O)NC(=O)C(C)NC(=O)C4CCC(=O)N4)C(N)=O

Gene Information

human ... INS(3630)

Biochem/physiol Actions

Potent hypotensive; induces salivation, intestinal contraction and vasodilation

Other Notes

Tachykinin originally isolated from the skin of the amphibian, Physalaemus fuscumaculatus; with structural homology to substance P

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Certificates of Analysis (COA)

Lot/Batch Number
087H1521
087H15212
087H15211
044K0829
122K0999

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Anjali Dike et al.
Journal of structural biology, 156(3), 442-452 (2006-09-19)
Uperolein, a physalaemin-like endecapeptide, has been shown to be selective for Neurokinin 1 receptor. As a first step towards understanding the structure-activity relationship, we report the membrane-induced structure of Uperolein with the aid of circular dichroism and 2D (1)H NMR
Christy Rani R Grace et al.
Biopolymers, 96(3), 252-259 (2010-07-16)
Physalaemin (PHY), a non-mammalian tachykinin, binds selectively to neurokinin-1 (NK1) receptor with high affinity. Both the aqueous and lipid-induced conformations of PHY have been studied using two-dimensional nuclear magnetic resonance techniques. These data show that in water PHY prefers to
S Lobasso et al.
Archives of physiology and biochemistry, 105(4), 329-336 (1998-08-26)
The effects of the non-mammalian tachykinin physalaemin were studied on the short circuit current (SCC) and on both influx (Ji) and outflux (Jo) of 36Cl- and 22Na+ across the isolated skin of Rana esculenta. Physalaemin, added to the internal bathing
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