Key Documents

GW583340 dihydrochloride

Name: GW583340 dihydrochloride
Brand: SIGMA

≥97% (HPLC), solid

Synonym(s):

4-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenylamino]-6-[2-[[2-(methylsulfonyl)ethyl]aminomethyl]-4-thiazolyl]quinazoline dihydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₂₈H₂₅ClFN₅O₃S₂ · 2HCl

CAS Number:

1173023-85-2

Molecular Weight:

671.03

NACRES:

NA.77

PubChem Substance ID:

24895131

UNSPSC Code:

51111800

MDL number:

MFCD07370137

Assay:

≥97% (HPLC)

Form:

solid

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Properties

assay

≥97% (HPLC)

form

solid

mp

259.8-262.4 °C (lit.)

solubility

DMSO: 9 mg/mL

originator

GlaxoSmithKline

storage temp.

2-8°C

SMILES string

Cl[H].Cl[H].CS(=O)(=O)CCNCc1nc(cs1)-c2ccc3ncnc(Nc4ccc(OCc5cccc(F)c5)c(Cl)c4)c3c2

InChI

1S/C28H25ClFN5O3S2.2ClH/c1-40(36,37)10-9-31-14-27-35-25(16-39-27)19-5-7-24-22(12-19)28(33-17-32-24)34-21-6-8-26(23(29)13-21)38-15-18-3-2-4-20(30)11-18;;/h2-8,11-13,16-17,31H,9-10,14-15H2,1H3,(H,32,33,34);2*1H

InChI key

WIMITXDBYLKRKB-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Potent dual ErbB-2/EGFR tyrosine kinase inhibitor. IC₅₀= 0.01 and 0.014 μM for EGFR and ErbB-2. Orally active.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

Sold for research purposes under agreement from GlaxoSmithKline

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This Item	D052	SML1205	SML1805
Sigma-Aldrich G3545 GW583340 dihydrochloride	Sigma-Aldrich D052 GBR 12909 dihydrochloride	Sigma-Aldrich SML1205 BVT.2733	Sigma-Aldrich SML1805 APS-2-79 hydrochloride
assay ≥97% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
form solid	form solid	form powder	form powder
storage temp. 2-8°C	storage temp. -	storage temp. 2-8°C	storage temp. 2-8°C
solubility DMSO: 9 mg/mL	solubility DMSO: >5 mg/mL (Solutions freshly prepared daily)	solubility DMSO: 20 mg/mL, clear	solubility DMSO: 10 mg/mL, clear
originator GlaxoSmithKline	originator -	originator -	originator -
mp 259.8-262.4 °C (lit.)	mp -	mp -	mp -

pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number

015K4703

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