F2177

Follistatin 288 from mouse

>95% (SDS-PAGE), recombinant, expressed in baculovirus infected Sf21 cells, lyophilized powder

• Synonym(s): FS-288
• UNSPSC Code: 51111800
• NACRES: NA.32
• MDL number: MFCD03456879

Properties

• biological source: mouse
• Quality Segment: 100
• recombinant: expressed in baculovirus infected Sf21 cells
• assay: >95% (SDS-PAGE)
• form: lyophilized powder
• potency: 0.04-0.4 mg per mL
• mol wt: calculated mol wt ~31 kDa
• packaging: pkg of 25 μg
• storage condition: avoid repeated freeze/thaw cycles
• impurities: endotoxin, tested
• UniProt accession no.: P47931
• storage temp.: −20°C
• Gene Information: mouse ... Fst(14313)

Description

General description

FST (follistatin) is an activin-binding protein, and exists in two isoforms due to alternate splicing, FS288 and FS315. It is a glycoprotein with a single chain, and acts as an activin antagonist. It has a high level of expression in fetal membranes and placenta.[1][2][3]

Biochem/physiol Actions

FST (follistatin) binds to and regulates activins, which in turn are TGF (transforming growth factor)-β superfamily members. The expression level of FST and its binding partner activin A is elevated in inflammatory disorders.[1] The activin A-follistatin system plays an essential role in the modulation of glucose and lipid metabolism, which might have an overall effect on fetal growth. In adipose tissue, it facilitates the adipogenic differentiation of progenitor cells.[3]

High affinity activin-binding protein that can act as an activin antagonist.

Physical form

Recombinant Mouse Follistatin 288 is supplied as a approximately 25 μg of protein lyophilized from a 0.2 μm filtered solution in 30% acetonitrile and 0.1% TFA containing 1.25 mg of bovine serum albumin.

Analysis Note

The biological activity is measured by its ability to neutralize activin-induced erythroid differentiation on K562 cells.

Safety Information

• pictograms: GHS05
• signalword: Danger
• hcodes: H315,H318
• Hazard Classifications: Eye Dam. 1 - Skin Irrit. 2
• Storage Class: 11 - Combustible Solids
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• pcodes: P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P362 + P364
• wgk: WGK 1