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Dimebon dihydrochloride hydrate

Name: Dimebon dihydrochloride hydrate
Brand: SIGMA

≥98% (HPLC)

Synonym(s):

2,8-Dimethyl-5-[2-(6-methyl-3-pyridinyl)ethyl]-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole dihydrochloride hydrate, Dimebolin dihydrochloride hydrate, Dimeboline dihydrochloride hydrate, Dimebone dihydrochloride hydrate

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About This Item

Empirical Formula (Hill Notation):

C₂₁H₂₅N₃ · 2HCl · xH₂O

CAS Number:

97657-92-6

Molecular Weight:

392.37 (anhydrous basis)

NACRES:

NA.77

PubChem Substance ID:

329798824

UNSPSC Code:

12352200

MDL number:

MFCD17215933

Assay:

≥98% (HPLC)

Form:

powder

Pricing and availability is not currently available.

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Properties

Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to off-white

solubility

H₂O: ≥10 mg/mL

storage temp.

2-8°C

SMILES string

O.Cl.Cl.CN1CCc2c(C1)c3cc(C)ccc3n2CCc4ccc(C)nc4

InChI

1S/C21H25N3.2ClH.H2O/c1-15-4-7-20-18(12-15)19-14-23(3)10-9-21(19)24(20)11-8-17-6-5-16(2)22-13-17;;;/h4-7,12-13H,8-11,14H2,1-3H3;2*1H;1H2

InChI key

QQHQMWVYYVVAOV-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Mechanism of neuroprotection and cognition enhancement is not certain, but Dimebon blocks both cholinesterase and the NMDA receptor simultaneously and also appears to block the action of neurotoxic β-amyloid proteins and inhibit L-type calcium channels, and may exert a neuroprotective effect by blocking a novel target that involves mitochondrial pores.

Features and Benefits

This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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This Item	SML2774	SML0588	T2705
Sigma-Aldrich D6196 Dimebon dihydrochloride hydrate	Sigma-Aldrich SML2774 KDOAM25 hydrochloride hydrate	Sigma-Aldrich SML0588 CP-94,253 dihydrochloride	Sigma-Aldrich T2705 Topotecan hydrochloride hydrate
form powder	form powder	form powder	form powder
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC and enzymatic)
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. 2-8°C	storage temp. −20°C	storage temp. room temp	storage temp. −20°C
solubility H₂O: ≥10 mg/mL	solubility H₂O: 2 mg/mL, clear	solubility H₂O: 15 mg/mL, clear	solubility DMSO: ≥20 mg/mL
color white to off-white	color white to beige	color white to beige	color yellow