Key Documents

DPPE hydrochloride

Name: DPPE hydrochloride
Brand: SIGMA

≥98% (HPLC)

Synonym(s):

BMS-217380-01, N,N-Diethyl-2-[4-(phenylmethyl) phenoxy]ethanamine hydrochloride, Tesmilifene hydrochloride, YMB1002, [2-(4-Benzyl-phenoxy)-ethyl]-diethyl-amine hydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₁₉H₂₅NO·HCl

CAS Number:

92981-78-7

Molecular Weight:

319.87

NACRES:

NA.77

PubChem Substance ID:

329798745

UNSPSC Code:

51111800

MDL number:

MFCD11114012

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

Pricing and availability is not currently available.

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Properties

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white

solubility

H₂O: 16 mg/mL

storage temp.

2-8°C

SMILES string

Cl.CCN(CC)CCOc1ccc(Cc2ccccc2)cc1

InChI

1S/C19H25NO.ClH/c1-3-20(4-2)14-15-21-19-12-10-18(11-13-19)16-17-8-6-5-7-9-17;/h5-13H,3-4,14-16H2,1-2H3;1H

InChI key

TXLHNFOLHRXMAU-UHFFFAOYSA-N

Description

Biochem/physiol Actions

DPPE is a potent, selective ligand of the microsomal anti-estrogen binding site.

DPPE is a potent, selective ligand of the microsomal anti-estrogen binding site. DPPE is a tamoxifen derivataive that binds with high affinity to the anti-estrogen binding site, but unlike tamoxifen, does not bind to the estrogen receptor. DPPE sensitizes MDR tumor cells to chemotherapy and also inhibits histamine binding at the intracellular histamine site.

Features and Benefits

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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This Item	SML0667	SML1805	SML0853
Sigma-Aldrich D2571 DPPE hydrochloride	Sigma-Aldrich SML0667 PF-429242 dihydrochloride	Sigma-Aldrich SML1805 APS-2-79 hydrochloride	Sigma-Aldrich SML0853 SB 699551 dihydrochloride
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
form powder	form powder	form powder	form powder
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C
solubility H₂O: 16 mg/mL	solubility H₂O: 15 mg/mL, clear	solubility DMSO: 10 mg/mL, clear	solubility H₂O: 1 mg/mL, clear (warmed)
color white	color white to beige	color white to beige	color white to beige

Storage Class

11 - Combustible Solids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number

020M4605

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Articles

Nuclear Receptors (Steroids)

We offers many products related to Nuclear Receptors (Steroids) for your research needs.

On-demand generation of an efficient catalyst for pyridine formation from unactivated nitriles and alpha,omega-diynes using CoCl2-6H2O, dppe, and Zn.

Kouki Kase et al.

Organic letters, 9(5), 931-934 (2007-01-31)

[reaction: see text] A highly practical, general method for catalytic formation of substituted pyridines from a variety of unactivated nitriles and alpha,omega-diynes is given. The reactions which were catalyzed by 5 mol % of dppe/CoCl2-6H2O in the presence of Zn

Effects of tesmilifene, a substrate of CYP3A and an inhibitor of P-glycoprotein, on the pharmacokinetics of intravenous and oral docetaxel in rats.

Young H Choi et al.

The Journal of pharmacy and pharmacology, 62(8), 1084-1088 (2010-07-29)

It has been reported that docetaxel is a P-glycoprotein substrate and is metabolized via the cytochrome P450 (CYP) 3A subfamily in rats. Tesmilifene is a substrate of the CYP3A subfamily and is an inhibitor of P-glycoprotein. Thus, the effects of

Phase III study of N,N-diethyl-2-[4-(phenylmethyl) phenoxy]ethanamine (BMS-217380-01) combined with doxorubicin versus doxorubicin alone in metastatic/recurrent breast cancer: National Cancer Institute of Canada Clinical Trials Group Study MA.19.

Leonard Reyno et al.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 22(2), 269-276 (2004-01-15)

N,N-diethyl-2-[4-(phenylmethyl)phenoxy]ethanamine (DPPE; tesmilifene) is a novel agent that augments chemotherapy cytotoxicity in vitro and in vivo. A phase II trial combining DPPE and doxorubicin (DOX) in metastatic breast carcinoma showed increased response over that expected with DOX. We report a

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DPPE hydrochloride

≥98% (HPLC)

Select a Size

About This Item

Quality Level

assay

form

color

solubility

storage temp.

SMILES string

InChI

InChI key

Biochem/physiol Actions

Features and Benefits

Compare Similar Items

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Storage Class

wgk

flash_point_f

flash_point_c

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