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Cloricromene

Name: Cloricromene
Brand: SIGMA

≥98% (HPLC), solid

Synonym(s):

8-Chloro-3-(2-diethylaminoethyl)-7-ethoxycarbonylmethoxy-4-methylcoumarin hydrochloride, AD6

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About This Item

Empirical Formula (Hill Notation):

C₂₀H₂₆ClNO₅ · HCl

CAS Number:

74697-28-2

Molecular Weight:

432.34

NACRES:

NA.77

PubChem Substance ID:

24892703

UNSPSC Code:

12352200

MDL number:

MFCD06409251

Assay:

≥98% (HPLC)

Form:

solid

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Properties

assay

≥98% (HPLC)

form

solid

color

white

mp

221-222.3 °C

solubility

DMSO: 17 mg/mL, H₂O: insoluble

storage temp.

2-8°C

SMILES string

Cl[H].CCOC(=O)COc1ccc2C(C)=C(CCN(CC)CC)C(=O)Oc2c1Cl

InChI

1S/C20H26ClNO5.ClH/c1-5-22(6-2)11-10-15-13(4)14-8-9-16(26-12-17(23)25-7-3)18(21)19(14)27-20(15)24;/h8-9H,5-7,10-12H2,1-4H3;1H

InChI key

CCCZJRFQJNGCCU-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Antithrombotic coumarin derivative that inhibits platelet and leukocyte function and suppresses arachidonic acid liberation by interfering with PLA₂activation.

pictograms

GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number

064K4620

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Multiple actions of the coumarine derivative cloricromene and its protective effects on ischemic brain injury.

G Calapai et al.

Naunyn-Schmiedeberg's archives of pharmacology, 351(2), 209-215 (1995-02-01)

The effects of different doses (0.25, 0.5, 1 and 2 mg/kg i.p.) of cloricromene, a coumarine derivative, have been investigated on brain malondialdehyde levels, brain edema, myeloperoxidase activity, survival, locomotor hyperactivity and hippocampal neuronal loss following transient cerebral ischemia induced

Tumor necrosis factor induces E-selectin production in splanchnic artery occlusion shock.

D Altavilla et al.

The American journal of physiology, 268(4 Pt 2), H1412-H1417 (1995-04-01)

Splanchnic arteries were clamped for 45 min to induce splanchnic artery occlusion (SAO) shock in anesthetized rats. Sham-operated animals were used as controls. Survival time, serum tumor necrosis factor-alpha (TNF-alpha), white blood cell (WBC) count, mean arterial blood pressure, myeloperoxidase

Liquefying Compounds by Forming Deep Eutectic Solvents: A Case Study for Organic Acids and Alcohols.

Dinis O Abranches et al.

The journal of physical chemistry. B, 124(20), 4174-4184 (2020-04-24)

The criterion to distinguish a simple eutectic mixture from a deep eutectic solvent (DES) lies in the deviations to thermodynamic ideality presented by the components in the system. In this work, the current knowledge of the molecular interactions in types