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Chlorprothixene hydrochloride

Name: Chlorprothixene hydrochloride
Brand: SIGMA

Synonym(s):

2-Chloro-9-(3-dimethylaminopropylidene)thioxanthene hydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₁₈H₁₈ClNS · HCl

CAS Number:

6469-93-8

Molecular Weight:

352.32

NACRES:

NA.77

PubChem Substance ID:

24278300

UNSPSC Code:

12352200

EC Number:

229-289-3

MDL number:

MFCD01941605

Form:

powder

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Properties

form

powder

storage temp.

2-8°C

SMILES string

Cl.CN(C)CC\C=C1\c2ccccc2Sc3ccc(Cl)cc13

InChI

1S/C18H18ClNS.ClH/c1-20(2)11-5-7-14-15-6-3-4-8-17(15)21-18-10-9-13(19)12-16(14)18;/h3-4,6-10,12H,5,11H2,1-2H3;1H/b14-7-;

InChI key

YWKRLOSRDGPEJR-KIUKIJHYSA-N

Gene Information

human ... DRD2(1813), DRD3(1814), HTR2A(3356), HTR2C(3358)

Description

General description

Chlorprothixene is a neuroleptic drug, which belongs to thioxanthene group. It has anticholinergic effects. Chlorprothixene might be associated with obstructive jaundice and parkinsonism. It is used to treat psychosis.

Application

Chlorprothixene hydrochloride has been used to study its exposure effects on learning and memory of rats.

Biochem/physiol Actions

D₂ dopamine receptor antagonist; blocks a subset of GABA_A receptors in rat cortex that is also blocked by clozapine; thioxanthine antipsychotic.

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This Item	C1915000	P4670	E5406
Sigma-Aldrich C1671 Chlorprothixene hydrochloride	C1915000 Chlorprothixene hydrochloride	Sigma-Aldrich P4670 Propafenone hydrochloride	Sigma-Aldrich E5406 Ethopropazine hydrochloride
form powder	form -	form powder	form powder
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C
Gene Information human ... DRD2(1813), DRD3(1814), HTR2A(3356), HTR2C(3358)	Gene Information human ... DRD2(1813), DRD3(1814), HTR2A(3356), HTR2C(3358)	Gene Information human ... ABCB1(5243), ADRB1(153), ADRB2(154), ADRB3(155), CYP1A2(1544), SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)	Gene Information human ... CHRM1(1128)

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pictograms

GHS06

signalword

Danger

hcodes

H301

pcodes

P301 + P310

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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In vivo whole-cell recording from morphologically identified mouse superior colliculus neurons.

Robin Broersen et al.

STAR protocols, 4(1), 101963-101963 (2022-12-22)

In vivo whole-cell recording, when combined with morphological characterization after biocytin labeling, is a powerful technique to study subthreshold synaptic processing in cell-type-identified neuronal populations. Here, we describe steps for performing whole-cell recordings in the superior colliculus of urethane-anesthetized mice, a

Distinct in vivo dynamics of excitatory synapses onto cortical pyramidal neurons and parvalbumin-positive interneurons.

Joshua B Melander et al.

Cell reports, 37(6), 109972-109972 (2021-11-11)

Cortical function relies on the balanced activation of excitatory and inhibitory neurons. However, little is known about the organization and dynamics of shaft excitatory synapses onto cortical inhibitory interneurons. Here, we use the excitatory postsynaptic marker PSD-95, fluorescently labeled at

Effect of some psychotropic drugs on the activated macrophage-induced luminol-dependent chemiluminescence.

V Hadjimitova et al.

Pharmacology & toxicology, 84(4), 170-173 (1999-05-05)

The effect of some psychotropic drugs on the activity of macrophages to produce superoxide radicals during phagocytosis was tested. Three-cyclic antidepressants, imipramine and amitriptyline, and the thioxanthene neuroleptic, chlorprothixene, were studied. The superoxide production was measured by luminol-dependent chemiluminescence. The