B3756
8-Bromoadenosine 5′-triphosphate sodium salt
≥90% (HPLC)
Synonym(s):
8-Br-ATP
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About This Item
Linear Formula:
C10H15N5O13P3Br
CAS Number:
Molecular Weight:
586.08
NACRES:
NA.51
PubChem Substance ID:
UNSPSC Code:
41106305
MDL number:
Pricing and availability is not currently available.
Quality Level
assay
≥90% (HPLC)
form
powder
storage temp.
−20°C
SMILES string
[Na].Nc1ncnc2n(C3OC(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)C(O)C3O)c(Br)nc12
InChI
1S/C10H15BrN5O13P3.Na.H/c11-10-15-4-7(12)13-2-14-8(4)16(10)9-6(18)5(17)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21;;/h2-3,5-6,9,17-18H,1H2,(H,22,23)(H,24,25)(H2,12,13,14)(H2,19,20,21);;
InChI key
BWSZHFBRMPXNSH-UHFFFAOYSA-N
Application
8-Bromoadenosine 5′-triphosphate (8-Br-ATP) is as an ATP analogue used in conjunction with other ATP analogues to study and resolve ATP-site binding effects on receptor and enzyme function and specificity.
Biochem/physiol Actions
P2X purinoceptor agonist similar in reactivity to ATP.
Other Notes
8-Bromo form of adenosine 5′-triphosphate.
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This Item | |||
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| Quality Level 200 | Quality Level 200 | Quality Level - | Quality Level 200 |
| storage temp. −20°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. −20°C |
| assay ≥90% (HPLC) | assay 99% | assay ≥98% | assay ≥97% (HPLC) |
| form powder | form - | form crystals | form powder |
Storage Class
11 - Combustible Solids
wgk
WGK 3
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
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Hiroyuki Iwamoto
Journal of muscle research and cell motility, 29(1), 45-55 (2008-07-11)
Previous studies using solubilized fragments of myosins have shown that an ATP analogue, 8-bromoadenosine triphosphate (8-Br-ATP) is a poor substrate for fast skeletal myosin isoform. We further characterized the analogue by using vertebrate skeletal muscle fibers. In the absence of
S A Thomas et al.
British journal of pharmacology, 103(4), 1963-1969 (1991-08-01)
1. Extracellular adenosine 5'-triphosphate (ATP) activated an early excitatory conductance followed by a late potassium conductance in developing chick skeletal muscle. A series of ATP analogues were tested for their ability to activate these two conductances. All compounds tested were
J Stutchfield et al.
FEBS letters, 262(2), 256-258 (1990-03-26)
We have recently characterised the presence of a Ca2(+)-mobilising receptor for ATP which stimulates exocytosis in differentiated HL60 cells. Here we demonstrate that the undifferentiated HL60 cells also respond to extracellular ATP by stimulating an increase in inositol phosphates and