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B019

Phenoxybenzamine hydrochloride

≥97%, powder

Synonym(s):

N-(2-Chloroethyl)-N-(1-methyl-2-phenoxyethyl)benzylamine hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C18H22ClNO · HCl
CAS Number:
63-92-3
Molecular Weight:
340.29
NACRES:
NA.77
PubChem Substance ID:
24277760
UNSPSC Code:
12352116
EC Number:
200-569-7
MDL number:
MFCD00055152
Assay:
≥97%
Form:
powder
Quality level:
100
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Quality Level

100

assay

≥97%

form

powder

color

white

solubility

H2O: slightly soluble, alcohol: soluble, propylene glycol: soluble

originator

Wellspring

storage temp.

2-8°C

SMILES string

Cl[H].CC(COc1ccccc1)N(CCCl)Cc2ccccc2

InChI

1S/C18H22ClNO.ClH/c1-16(15-21-18-10-6-3-7-11-18)20(13-12-19)14-17-8-4-2-5-9-17;/h2-11,16H,12-15H2,1H3;1H

InChI key

VBCPVIWPDJVHAN-UHFFFAOYSA-N

Gene Information

human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152)

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Biochem/physiol Actions

Calmodulin antagonist; α-adrenoceptor antagonist.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Wellspring. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Warning

hcodes

H302,H351

Hazard Classifications

Acute Tox. 4 Oral - Carc. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

Lot/Batch Number
MKCZ2037
MKCN3537
MKCL8599
MKCK4939
MKCD4626

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Is dexmedetomidine the agent of choice in the resection of pheochromocytoma?
Harsha V Polavarapu et al.
The American surgeon, 78(3), E127-E128 (2012-04-25)
Yu Zhu et al.
Endocrine, 38(2), 254-259 (2010-11-04)
The objective of this article is to evaluate the efficacy of Doxazosin Mesylate Controlled Release Tablets for preoperative treatment of patients with pheochromocytoma. Between 2003 and 2008, 67 patients with confirmed diagnoses of pheochromocytoma were enrolled in this study. According
Elif Cadirci et al.
Critical care medicine, 38(9), 1860-1867 (2010-07-06)
Adrenal gland hormones have been shown to have a role in the antiinflammatory effect mechanism of nonsteroidal antiinflammatory drugs. This study investigates whether the analgesic effects of indomethacin, diclofenac sodium, aspirin, and nimesulide (IDAN; upper case letters of the four
Hasan K Siddiqi et al.
Surgery, 152(6), 1027-1036 (2012-11-20)
Calcium channel blockade with nicardipine (NC) is an alternative to phenoxybenzamine (PB) preparation for resection of a pheochromocytoma. Intraoperative magnesium sulfate infusion (+MgSO(4)) is often used for its cardiovascular stabilizing properties. We hypothesized that preparation with NC would be similar
P A van Zwieten et al.
Annals of the New York Academy of Sciences, 522, 351-360 (1988-01-01)
A survey is given of the interaction between alpha-adrenoceptor-triggered vasoconstriction and the influx of extracellular calcium ions. This problem was investigated by studying the influence of calcium entry blockers (CEB) on the vasoconstriction induced by several types of alpha 2-
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