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BI-6C9

Name: BI-6C9
Brand: SIGMA

≥97% (HPLC), solid

Synonym(s):

N-[4-[(4-Aminophenyl)thio]phenyl]-4-[[(4-methoxyphenyl)sulfonyl]amino]-Butanamide

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About This Item

Empirical Formula (Hill Notation):

C₂₃H₂₅N₃O₄S₂

CAS Number:

791835-21-7

Molecular Weight:

471.59

NACRES:

NA.77

PubChem Substance ID:

24724408

UNSPSC Code:

12352200

MDL number:

MFCD07784498

Assay:

≥97% (HPLC)

Form:

solid

Quality level:

100

Pricing and availability is not currently available.

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Properties

Quality Level

100

assay

≥97% (HPLC)

form

solid

color

off-white

solubility

DMSO: >20 mg/mL

storage temp.

−20°C

SMILES string

COc1ccc(cc1)S(=O)(=O)NCCCC(=O)Nc2ccc(Sc3ccc(N)cc3)cc2

InChI

1S/C23H25N3O4S2/c1-30-19-8-14-22(15-9-19)32(28,29)25-16-2-3-23(27)26-18-6-12-21(13-7-18)31-20-10-4-17(24)5-11-20/h4-15,25H,2-3,16,24H2,1H3,(H,26,27)

InChI key

LCFUJBSKPDPGKO-UHFFFAOYSA-N

Description

Biochem/physiol Actions

BI-6C9 is a tBid inhibitor and antiapoptotic.

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This Item	SML0917	B9308	G0544
Sigma-Aldrich B0186 BI-6C9	Sigma-Aldrich SML0917 BMS-986122	Sigma-Aldrich B9308 BP897	Sigma-Aldrich G0544 GR 103691
assay ≥97% (HPLC)	assay ≥98% (HPLC)	assay >98% (HPLC)	assay ≥98% (HPLC)
form solid	form powder	form solid	form solid
Quality Level 100	Quality Level 100	Quality Level -	Quality Level 100
storage temp. −20°C	storage temp. 2-8°C	storage temp. -	storage temp. 2-8°C
solubility DMSO: >20 mg/mL	solubility DMSO: 20 mg/mL, clear	solubility DMSO: soluble 10 mg/mL	solubility DMSO: soluble >5 mg/mL at 60 °C
color off-white	color white to beige	color off-white	color white

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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MRCKα is activated by caspase cleavage to assemble an apical actin ring for epithelial cell extrusion.

Paolo Armando Gagliardi et al.

The Journal of cell biology, 217(1), 231-249 (2017-11-23)

Extrusion of apoptotic cells from epithelial tissues requires orchestrated morphological rearrangements of the apoptotic cell and its neighbors. However, the connections between the apoptotic cascade and events leading to extrusion are not fully understood. Here, we characterize an apoptotic extrusion

Identification of Chaetocin as a Potent non-ROS-mediated Anticancer Drug Candidate for Gastric Cancer.

Xinwen Liao et al.

Journal of Cancer, 10(16), 3678-3690 (2019-07-25)

Chaetocin, a natural product extracted from Chaetomium species, possesses anticancer effects in several kinds of tumors. However, it remains unclear whether the potential indication for chaetocin could also include human gastric cancer. We found here that chaetocin induced caspase-dependent and

Tetrachlorobenzoquinone triggers the cleavage of Bid and promotes the cross-talk of extrinsic and intrinsic apoptotic signalings in pheochromocytoma (PC) 12 cells.

Lihua Hu et al.

Neurotoxicology, 49, 149-157 (2015-06-27)

Although there are few studies suggested PCP exposure induced developmental and behavioral disorders, however, the occurrence of neurotoxicity and PCP has not been firmly established. Tetrachlorobenzoquinone (TCBQ) is a reactive metabolite of environmental pollutant pentachlorophenol (PCP). To the best of