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α-Amylase Inhibitor

Name: α-Amylase Inhibitor
Brand: SIGMA

≥200 inhibitor U/mg protein (using porcine pancreatic α-amylase), ≥1000 inhibitor U/mg protein (using human salivary α-amylase), lyophilized powder

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About This Item

UNSPSC Code:

12352202

NACRES:

NA.77

MDL number:

MFCD00130475

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Properties

Product Name

α-Amylase Inhibitor from Triticum aestivum (wheat seed), Type I, lyophilized powder

biological source

Triticum estivum

Quality Segment

200

type

Type I

form

lyophilized powder

specific activity

≥1000 inhibitor U/mg protein (using human salivary α-amylase), ≥200 inhibitor U/mg protein (using porcine pancreatic α-amylase)

composition

Protein, 35-65% biuret

storage temp.

−20°C

Description

General description

α-Amylases are endoglycosidases, that are classified into glycosyl hydrolase family 13 (1-3).

Application

α-Amylase Inhibitor from Triticum aestivum (wheat seed) has been used to determine its effects on salivary gland (SG) amylase activity. It has also been used to inhibit the activity from the extract from Bemisia tabaci.

Biochem/physiol Actions

Competitive inhibitor of human salivary α-amylase. K_I = 2.9 nM, compared to a K_M of 5.9 mM (calculated per mole of α-1,4-linked maltose residues).

α-Amylases can hydrolyze α-(1,4)-D-glycosidic linkages. It participates in the breakdown of starch and glycogen. Inhibiting this enzyme can be used as a strategy to treat dental caries, diabetes, obesity and periodontal diseases.

Physical form

Lyophilized powder containing buffer salts as sodium phosphate.

Other Notes

One unit will reduce the activity of two units of α-amylase (A0521) by 50% after pre-incubation at 25 °C.

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This Item	10069	A6380	A4862
Sigma-Aldrich A1520 α-Amylase Inhibitor from Triticum aestivum (wheat seed)	Sigma-Aldrich 10069 α-Amylase from Bacillus sp.	Sigma-Aldrich A6380 α-Amylase from Bacillus sp.	Sigma-Aldrich A4862 α-Amylase from Bacillus sp.
biological source Triticum estivum	biological source Bacillus sp.	biological source bacterial (Bacillus amyloliquefaciens)	biological source Bacillus sp.
Quality Level 200	Quality Level 100	Quality Level 200	Quality Level 200
form lyophilized powder	form powder	form lyophilized powder	form liquid
storage temp. −20°C	storage temp. 2-8°C	storage temp. −20°C	storage temp. 2-8°C
specific activity ≥1000 inhibitor U/mg protein (using human salivary α-amylase), ≥200 inhibitor U/mg protein (using porcine pancreatic α-amylase)	specific activity ~380 U/mg	specific activity ≥1,500 units/mg protein (biuret)	specific activity -
type Type I	type -	type Type II-A	type -

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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