Skip to Content
Merck

Key Documents

View All Documentation

Skip To

A1075

Amyloid β Protein Fragment 1-40

≥90% (HPLC), powder

Synonym(s):

Aβ40

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View
Pack SizeSKUAvailabilityPrice

About This Item

Empirical Formula (Hill Notation):
C194H295N53O58S
CAS Number:
131438-79-4
Molecular Weight:
4329.80
UNSPSC Code:
12352202
NACRES:
NA.32
MDL number:
MFCD00130509
Form:
powder
Assay:
≥90% (HPLC)
Pricing and availability is not currently available.
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Quality Level

200

assay

≥90% (HPLC)

form

powder

color

white

solubility

1% acetic acid: 1 mg/mL, saline: insoluble

UniProt accession no.

P05067

storage temp.

−20°C

Gene Information

human ... APP(351)

General description

Amyloid β Protein Fragment 1-40 (Aβ40) is derived from the amyloid-β protein (Aβ), which is mapped to human chromosome 21q21.3. Aβ40 is predominantly present in the vascular amyloid deposits. Aβ40 comprises of C-terminal membrane insertion domain. It shows structural transition from random coil to a α-helical structure in a water-micelle medium.

Application

Amyloid β Protein Fragment 1-40 has been used:
  • in the temperature based conformational studies using Fourier transform infrared/differential scanning calorimetry (FT-IR/DSC) studies
  • as a reference standard in sandwich-type enzyme immunoassay for quantifying amyloid A4 protein in cerebrospinal fluid of patients with head trauma
  • as a component of embryonic stem cell medium to inhibit amyloid deposition in fibroblasts[1]

Biochem/physiol Actions

Amyloid β-protein is neurotrophic and neurotoxic in vivo and in vitro in human and rat neuronal cell cultures. β-Amyloid peptides (amino acids 1-42 and 1-43) are the major constituents of senile plaques and neurofibrillary tangles that occur in the hippocampus, neocortex, and amygdala of patients with Alzheimer′s disease.
Amyloid β Protein Fragment 1-40 (Aβ40) forms cation based ion channels.

Preparation Note

For maximal biological activity, dilute the stock in calcium-free PBS to 1 mg/ml and incubate at 37 °C for 4 days.

Other Notes

Lyophilized from 0.1% TFA in H2O

Compare Similar Items

View Full Comparison

Show Differences

1 of 1

This Item
A2326A7973AG968
Amyloid β Protein Fragment 1-40 ≥90% (HPLC), powder

Sigma-Aldrich

A1075

Amyloid β Protein Fragment 1-40

Amyloid β-Protein Fragment 40-1 ≥90% (HPLC)

Sigma-Aldrich

A2326

Amyloid β-Protein Fragment 40-1

[Arg13] Amyloid-β-Protein Fragment 1-40 ≥80% (HPLC), lyophilized powder

Sigma-Aldrich

A7973

[Arg13] Amyloid-β-Protein Fragment 1-40

β Amyloid 1-42, aβ, ultra pure, HFIP, recombinant human

Sigma-Aldrich

AG968

β Amyloid 1-42, aβ, ultra pure, HFIP, recombinant human

assay

≥90% (HPLC)

assay

≥90% (HPLC)

assay

≥80% (HPLC)

assay

>97.0%

form

powder

form

powder

form

lyophilized powder

form

(Clear dry film)

Gene Information

human ... APP(351)

Gene Information

human ... APP(351)

Gene Information

human ... APP(351)

Gene Information

human ... APP(351)

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

-

solubility

1% acetic acid: 1 mg/mL, saline: insoluble

solubility

-

solubility

H2O: soluble

solubility

-

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

100

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
0000496985
0000496985
0000400129
0000400129
0000327696

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Sandwich-Type Enzyme Immunoassay for Amyloid A4 Protein in Cerebrospinal Fluid From Patients with Head Trauma
PIRIM I
Turkish Journal of Medical Sciences, 31(1), 47-50 (2001)
Amyloid beta protein 1-40 and 1-42 levels in matched cerebrospinal fluid and plasma from patients with Alzheimer disease
Mehta PD, et al.
Neuroscience Letters, 304(1-2), 102-106 (2001)
K Ueda et al.
Brain research, 639(2), 240-244 (1994-03-14)
The neurotoxic effects of soluble and aggregated synthetic amyloid beta protein (A beta P) have been investigated in rat primary cultures. Freshly solubilized beta(1-40) was neurotoxic not to immature, but to mature hippocampal neurons. On the other hand, aggregated beta(1-40)
View All Related Papers

Questions

1–3 of 3 Questions  

  1. What is the Department of Transportation shipping information for this product?

    1 answer

    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

      Helpful?

  2. This product has a temperature storage of -20 C on the label, but the material did not come on ice. Is the product still good?

    1 answer

    1. Where there may short-term exposure (I.e. during shipment) to conditions other than those recommended for long-term storage that will not affect product quality, Sigma-Aldrich will ship at ambient temperature.

      Helpful?

  3. Which document(s) contains shelf-life or expiration date information for a given product?

    1 answer

    1. If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

      Helpful?

Reviews

No rating value

Active Filters