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52194

Tetramethylrhodamine isothiocyanate–Dextran

average mol wt 500,000

Synonym(s):

TRITC Dextran, TRITC-Dextran 500, TRITC-Dextran

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About This Item

UNSPSC Code:
12352116
NACRES:
NA.32
MDL number:
Pricing and availability is not currently available.
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biological source

synthetic

Quality Level

form

powder or crystals

mol wt

average mol wt 500,000

extent of labeling

0.001-0.008 mol/mol TRITC glucose

fluorescence

λex 550 nm; λem 575 nm±5 nm in 0.1 M Tris pH 8.0

application(s)

cell analysis

General description

Tetramethylrhodamine isothiocyanate–Dextran, also known as TRITC-Dextran or TRITC-Dextran 500, is a fluorescent dye and a novel drug. The fluorescent activity of TRITC-Dextran is detected at 555nm wavelength. [1]The TRITC-Dextran molecules are released in the cells through passive diffusion due to a concentration gradient.[2]

Application

Tetramethylrhodamine isothiocyanate–Dextran (TRITC-Dextran 500) is use as a fluorescent probe to study cell processes such as cell permeability, phagocytosis and endocytosis and to study mechanisms of biomolecular delivery.

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This Item
42874T1287T1162
biological source

synthetic

biological source

synthetic

biological source

synthetic (organic)

biological source

-

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

form

powder or crystals

form

powder

form

powder

form

powder

extent of labeling

0.001-0.008 mol/mol TRITC glucose

extent of labeling

0.001-0.008 mol/mol TRITC glucose

extent of labeling

~1 TRITC per 100 glucose residues

extent of labeling

~1 TRITC per 100 glucose residues

application(s)

cell analysis

application(s)

cell analysis

application(s)

-

application(s)

-

mol wt

average mol wt 500,000

mol wt

average mol wt 40,000

mol wt

average mol wt 155,000

mol wt

average mol wt 65,000-85,000


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pictograms

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signalword

Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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Articles

Explore FITC-labelled polysaccharides and their properties, including impact of molecular weight on molecule dimensions.


Thea van der Wijk et al.
The Journal of biological chemistry, 278(41), 40020-40025 (2003-07-23)
Osmotic swelling of Intestine 407 cells leads to an immediate increase in cell surface membrane area as determined using the fluorescent membrane dye FM 1-43. In addition, as measured by tetramethylrhodamine isothiocyanate (TRITC)-dextran uptake, a robust (>100-fold) increase in the
Margaret Clarke et al.
Journal of cell science, 115(Pt 14), 2893-2905 (2002-06-26)
The vacuolar H(+)-ATPase (V-ATPase) is a multi-subunit enzyme that plays important roles in eukaryotic cells. In Dictyostelium, it is found primarily in membranes of the contractile vacuole complex, where it energizes fluid accumulation by this osmoregulatory organelle and also in
Ngo Bich Nga Nathalie Tran et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 116, 12-16 (2016-10-25)
Hair follicle research is currently focused on the development of drug-loaded nanocarriers for the targeting of follicular structures in the treatment of skin and hair follicle-related disorders. In the present study, a dual-label nanocarrier system was implemented in which FITC-labeled



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