The solubility of this product has not been determined. However, the cell culture tested (±)-α-Lipoic acid, product T1395, is soluble at 50 mg/mL in ethanol. Similar solubility is expected for this item. In addition, various sources indicate this compound is also soluble in DMSO, acetonitrile, and chloroform. This information has not been validated.
07039
(R)-(+)-α-Lipoic acid
≥98.0% (HPLC)
Synonym(s):
(R)-(+)-1,2-Dithiolane-3-pentanoic acid, (R)-6,8-Dithiooctanoic acid, (R)-6,8-Thioctic acid
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About This Item
Empirical Formula (Hill Notation):
C8H14O2S2
CAS Number:
Molecular Weight:
206.33
UNSPSC Code:
12352202
PubChem Substance ID:
NACRES:
NA.32
MDL number:
Pricing and availability is not currently available.
Quality Level
assay
≥98.0% (HPLC)
optical purity
enantiomeric excess: ≥98.0% (HPLC)
mp
48-52 °C (lit.)
storage temp.
−20°C
InChI
1S/C8H14O2S2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H,9,10)/t7-/m1/s1
InChI key
AGBQKNBQESQNJD-SSDOTTSWSA-N
Biochem/physiol Actions
(R)-(+)-α-Lipoic acid was shown to significantly increase pyruvate oxidation while abrogating fatty acid oxidation in rat hepatocytes. These effects make R-(+)-α-Lipoic acid a promising treatment option for the treatment of Type II diabetes.[1] It is a biological antioxidant with prooxidant activities[2][3], its therapeutic potential is widely investigated[4][5][6], e.g. in the treatment for Alzheimer′s disease.[7]
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
Analysis Note
identity confirmed by LC-MS
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This Item | |||
|---|---|---|---|
| Quality Level 100 | Quality Level 100, 200 | Quality Level 100 | Quality Level - |
| assay ≥98.0% (HPLC) | assay ≥97% (HPLC) | assay ≥98.0% (HPLC) | assay - |
| storage temp. −20°C | storage temp. −20°C | storage temp. 2-8°C | storage temp. 2-8°C |
| mp 48-52 °C (lit.) | mp - | mp 48-52 °C (lit.) | mp - |
| optical purity enantiomeric excess: ≥98.0% (HPLC) | optical purity enantiomeric excess: ≥98.0% (HPLC) | optical purity - | optical purity - |
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Storage Class
11 - Combustible Solids
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WGK 3
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Jennie L Walgren et al.
Metabolism: clinical and experimental, 53(2), 165-173 (2004-02-10)
R-(+)-alpha-lipoic acid (R-LA) is the naturally occurring enantiomer of LA. It is a strong antioxidant and cofactor of key metabolic enzyme complexes catalyzing the decarboxylation of alpha-keto acids. Racemic LA (rac-LA) has shown promise in treating diabetic polyneuropathy, and some
Takashi Yamada et al.
Neurochemistry international, 59(7), 1003-1009 (2011-10-13)
Growing evidence suggests that α-lipoic acid (LA) has neuroprotective effects in various pathological conditions including brain ischemia and neurodegeneration. While anti-oxidative activity has been thought to play a central role in LA-mediated neuroprotection, the precise mechanism and the effect of
Dove J Keith et al.
Pharmacological research, 66(3), 199-206 (2012-05-23)
Lipoic acid (LA) shows promise as a beneficial micronutrient toward improving elder health. Studies using old rats show that (R)-α-LA (R-LA) significantly increases low molecular weight antioxidants that otherwise decline with age. Despite this rationale for benefiting human health, little
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