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D1065

4-(2-[6-(Dioctylamino)-2-naphthalenyl]ethenyl)-1-(3-sulfopropyl)pyridinium inner salt

≥95% purity (HPLC), solid

Synonym(s):

Di-8-ANEPPS

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About This Item

Empirical Formula (Hill Notation):
C36H52N2O3S
CAS Number:
Molecular Weight:
592.87
UNSPSC Code:
12171500
PubChem Substance ID:
NACRES:
NA.47
MDL number:
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Product Name

4-(2-[6-(Dioctylamino)-2-naphthalenyl]ethenyl)-1-(3-sulfopropyl)pyridinium inner salt, ≥95% (HPLC), solid

Quality Level

assay

≥95% (HPLC)

form

solid

mol wt

592.88

color

orange to red

solubility

DMSO: soluble, ethanol: soluble

ε (extinction coefficient)

≥37 at 495-501  nm in methanol

fluorescence

λex 710-716 nm

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

2-8°C

SMILES string

CCCCCCCCN(CCCCCCCC)c1ccc2cc(\C=C\c3cc[n+](CCCS([O-])(=O)=O)cc3)ccc2c1

InChI

1S/C36H52N2O3S/c1-3-5-7-9-11-13-25-38(26-14-12-10-8-6-4-2)36-21-20-34-30-33(18-19-35(34)31-36)17-16-32-22-27-37(28-23-32)24-15-29-42(39,40)41/h16-23,27-28,30-31H,3-15,24-26,29H2,1-2H3

InChI key

IXFSUSNUALIXLU-UHFFFAOYSA-N

Biochem/physiol Actions

Fast-responding membrane potential dye.

Other Notes

More suitable for long-term membrane potential studies than di-4-ANEPPS (Cat. No. D8064) because of better retention in the outer leaflet of plasma membranes.

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This Item
D8064D0815A7222
fluorescence

λex 710-716 nm

fluorescence

-

fluorescence

-

fluorescence

-

color

orange to red

color

orange to dark red

color

red

color

beige to dark beige, yellow to dark yellow

form

solid

form

solid

form

solid

form

solid

application(s)

diagnostic assay manufacturing
hematology
histology

application(s)

diagnostic assay manufacturing
hematology
histology

application(s)

diagnostic assay manufacturing
hematology
histology

application(s)

diagnostic assay manufacturing
hematology
histology

solubility

DMSO: soluble, ethanol: soluble

solubility

DMF: soluble, DMSO: soluble, ethanol: soluble

solubility

DMSO: 0.5 mg/mL, methanol: soluble

solubility

-

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)



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Carlos A Valverde et al.
Cardiovascular research, 115(3), 556-569 (2018-09-01)
Abnormal Ca2+ release from the sarcoplasmic reticulum (SR), associated with Ca2+-calmodulin kinase II (CaMKII)-dependent phosphorylation of RyR2 at Ser2814, has consistently been linked to arrhythmogenesis and ischaemia/reperfusion (I/R)-induced cell death. In contrast, the role played by SR Ca2+ uptake under
Antonio Celestino-Montes et al.
Life sciences, 264, 118700-118700 (2020-11-02)
Ventricular myocytes (VM) depolarization activates L-type Ca2+ channels (LCC) allowing Ca2+ influx (ICa) to synchronize sarcoplasmic reticulum (SR) Ca2+ release, via Ca2+-release channels (RyR2). The resulting whole-cell Ca2+ transient triggers contraction, while cytosolic Ca2+ removal by SR Ca2+ pump (SERCA2)
Kate Hsu et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 31(10), 4256-4264 (2017-06-10)
Human CO



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