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Anti-SREBP1 Antibody, clone 2121

Name: Anti-SREBP1 Antibody, clone 2121
Brand: MM

clone 2121, Upstate^®, from mouse

Synonym(s):

SREBF1, sterol regulatory element binding transcription factor 1

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About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

eCl@ss:

32160702

Conjugate:

unconjugated

Clone:

2121, monoclonal

Application:

Citations:

Pricing and availability is not currently available.

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Properties

biological source

mouse

Quality Level

100

conjugate

unconjugated

antibody form

purified antibody

antibody product type

primary antibodies

clone

2121, monoclonal

species reactivity

human

packaging

antibody small pack of 25 μL

manufacturer/tradename

Upstate^®

technique(s)

western blot: suitable

isotype

IgG1

NCBI accession no.

NM_001005291.1, NM_004176.3

UniProt accession no.

P36956

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... SREBF1(6720)

Description

General description

126 kDa

Immunogen

Recombinant His-tagged human SREBP-1a protein encompassing amino acids 301-407.

Application

Anti-SREBP1 Antibody, clone 2121 is a Mouse Monoclonal Antibody for detection of SREBP1 also known as sterol regulatory element binding transcription factor 1 & has been validated in WB.

Biochem/physiol Actions

Reacts with the basic helix-loop-helix leucine zipper (bHLH-ZIP) of SREBP.

Physical form

100 μL (1 mg/mL) of protein A purified mouse monoclonal IgG1 in PBS with 0.1% sodium azide.

Format: Purified

Preparation Note

Stable for 2 years at -20°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.

Analysis Note

Routinely evaluated by immunoblot.

Other Notes

feature_concentration_valuePlease refer to lot specific datasheet.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

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1 of 1

This Item	SAB4502850	SAB1404405	WH0006720M1
Sigma-Aldrich 04-469 Anti-SREBP1 Antibody, clone 2121	Sigma-Aldrich SAB4502850 Anti-SREBP-1 antibody produced in rabbit	Sigma-Aldrich SAB1404405 Monoclonal Anti-SREBF1 antibody produced in mouse	Sigma-Aldrich WH0006720M1 Monoclonal Anti-SREBF1 antibody produced in mouse
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
biological source mouse	biological source rabbit	biological source mouse	biological source mouse
clone 2121, monoclonal	clone polyclonal	clone 4C11, monoclonal	clone 4B10, monoclonal
antibody form purified antibody	antibody form affinity isolated antibody	antibody form purified immunoglobulin	antibody form purified immunoglobulin
species reactivity human	species reactivity human, rat	species reactivity human	species reactivity human
shipped in dry ice	shipped in wet ice	shipped in dry ice	shipped in dry ice

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Journal of biochemical and molecular toxicology, 35(4), e22693-e22693 (2021-01-05)

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Nuclear protein that binds sterol regulatory element of low density lipoprotein receptor promoter. II. Purification and characterization.

X Wang et al.

The Journal of biological chemistry, 268(19), 14497-14504 (1993-07-05)

This paper describes the purification and characterization of a sterol regulatory element binding protein (SREBP) that recognizes the SRE-1 sequence in the 5' flanking region of the gene for the low density lipoprotein (LDL) receptor. The protein was purified more

Phosphorylation and ubiquitination of the transcription factor sterol regulatory element-binding protein-1 in response to DNA binding.

Tanel Punga et al.

The Journal of biological chemistry, 281(35), 25278-25286 (2006-07-11)

Members of the sterol regulatory element-binding protein (SREBP) family of transcription factors control cholesterol and lipid metabolism and play critical roles during adipocyte differentiation. The transcription factor SREBP1 is degraded by the ubiquitin-proteasome system following phosphorylation of Thr426 and Ser430