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Merck

1133580

USP

Oversulfated Chondroitin Sulfate

United States Pharmacopeia (USP) Reference Standard

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About This Item

分類程式碼代碼:
41116107
NACRES:
NA.24

等級

pharmaceutical primary standard

API 家族

heparin

製造商/商標名

USP

應用

pharmaceutical (small molecule)

格式

neat

一般說明

Oversulfated Chondroitin Sulfate (OSCS) is a prominent contaminant found in heparin that is connected to adverse clinical events. OSCS exhibits plasma anticoagulant activity and the capability to activate prekallikrein to kallikrein.

Oversulfated Chondroitin Sulfate USP reference standard is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia

應用

Oversulfated Chondroitin Sulfate USP reference standard suitable for use in specified USP compendial tests and assays. Also used to prepare system suitability solutions for the identification of heparin sodium by proton NMR (Nuclear magnetic resonance) spectroscopy and chromatography method.

Further information is available in the monograph, Heparin Sodium, USP43-NF38 - 2195 of the USP (United States Pharmacopeia).

其他說明

This product is part of the USP Biologics program.
Sales restrictions may apply.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Oversulfated Chondroitin Sulfate
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 41(6), 2195-2195 (2018)
The effect of increasing the sulfation level of chondroitin sulfate on anticoagulant specific activity and activation of the kinin system
Hogwood J, et al.
PLoS ONE (2018)
The effect of increasing the sulfation level of chondroitin sulfate on anticoagulant specific activity and activation of the kinin system
Hogwood J, et al.
Testing (2018)
Oversulfated chondroitin sulfate is a contaminant in heparin associated with adverse clinical events
Guerrini M, et al.
Nature Biotechnology (2008)

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