The cross reactivity of SRP6155 human BMP2 with rat has not been checked. However, literature indicates a high level of sequence homology between human and rat BMP2 (Freire et al., 2012; Freire et al., 2015) and VEGFA (Avivi et al., 1999; Ferrara, 2002) proteins. Accordingly, in many studies, human recombinant BMP2 and VEGFA have been used successfully in bone regeneration experiments in the rat (Park et al., 2003; Li et al., 2016). It is likely that SRP6155 should work with rat samples.
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一般描述
BMP2 (bone morphogenetic protein 2) belongs to the transforming growth factor-β (TGFβ) superfamily. BMP-2 is expressed in a variety of tissues such as lung, spleen, brain, liver, prostate ovary, and small intestine.[1] BioVision′s BMP-2 is produced in a serum-free, chemically defined media. Production in human 293 cells offers authentic glycosylation, contributing to stability in cell growth media and other applications.BMP2 is a candidate gene for the autosomal dominant disease of fibrodysplasia (myositis) ossificans progressiva.
应用
BMP-2 human has been used to study the biological role of it on adult renal progenitor cells under in vitro and in vivo conditions.[2]
生化/生理作用
BMPs (bone morphogenetic proteins) promote and regulate bone development, growth, remodeling and repair, in both prenatal development and postnatal growth of eye, heart, kidney, skin, and other tissues.[3] During bone repair, BMP-2 controls the expression of Runt-related transcription factor 2 (Runx2) and Osterix (Osx), thereby enhancing migration, proliferation and osteogenic differentiation of mesenchymal stem cells.[4] In addition to its osteogenic activity, BMP-2 also plays an important role in cardiac morphogenesis.[5]
外形
Lyophilized from a solution of 50 mM sodium acetate, pH 4.5, with 50 mM NaCl.
制备说明
Centrifuge the vial prior to opening.
重悬
Reconstitute in sterile PBS containing 0.1% endotoxin-free, recombinant human serum albumin.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
BMP-2 induces a profibrotic phenotype in adult renal progenitor cells through Nox4 activation.
Simone S, et al.
American Journal of Physiology: Renal Physiology, 303, F23-F34 (2012)
Nam Hee Kim et al.
Biomaterials, 35(37), 9888-9896 (2014-09-15)
Though growth factors allow tissue regeneration, the trade-off between their effectiveness and adverse effects limits clinical application. The key issues in current growth factor therapy largely derive from initial burst pharmacokinetics, rapid clearance, and proteolytic cleavage resulting in clinical ineffectiveness
N M Shah et al.
Cell, 85(3), 331-343 (1996-05-03)
How growth factors influence the fate of multipotent progenitor cells is not well understood. Most hematopoietic growth factors act selectively as survival factors, rather than instructively as lineage determination signals. In the neural crest, neuregulin instructively promotes gliogenesis, but how
Rick Visser et al.
Tissue engineering. Part A, 20(1-2), 34-44 (2013-07-19)
Osteogenesis is a complex, multifactorial process in which many different signals interact. The bone morphogenetic proteins (BMPs) are the most potent inducers of osteoblastic differentiation, although very high doses of BMPs in combination with collagen type I formulations have to
Vera Hintze et al.
Biomacromolecules, 15(8), 3083-3092 (2014-07-17)
Sulfated glycosaminoglycans (GAGs) can direct cellular processes by interacting with proteins of the extracellular matrix (ECM). In this study we characterize the interaction profiles of chemically sulfated hyaluronan (HA) and chondroitin sulfate (CS) derivatives with bone morphogenetic protein-2 (BMP-2) and
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Could you please provide information on the cross-reactivity of SRP6155 with rats?
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