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Merck
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主要文件

SML3078

Sigma-Aldrich

JT003 trifluoroacetate

≥95% (HPLC)

别名:

P-Nva-LYYFA trifluoroacetate

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About This Item

经验公式（希尔记法）:
C46H62N8O9 · xC2HF3O2
分子量:
871.03 (free base basis)
UNSPSC代码:
51111800
NACRES:
NA.77
价格与库存信息目前不能提供

质量水平

100

方案

≥95% (HPLC)

表单

film or powder

颜色

white to off-white

储存温度

−20°C

生化/生理作用

JT003 is potent dual agonist of adiponectin receptors AdipoR1/AdipoR2 that potently improves insulin resistance in high fat diet induced nonalcoholic steatohepatitis (NASH) mice. JT003 inhibits hepatic stellate cells (HSCs) activation in CCl4 induced liver fibrosis.
potent dual agonist of adiponectin receptors AdipoR1/AdipoR2

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000128011
0000126001

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Michishige Terasaki et al.
International journal of molecular sciences, 21(13) (2020-07-11)
Dipeptidyl peptidase-4 (DPP-4) inhibitors have been reported to play a protective role against atherosclerosis in both animal models and patients with type 2 diabetes (T2D). However, since T2D is associated with dyslipidemia, hypertension and insulin resistance, part of which are
Hongjiao Xu et al.
Nature communications, 11(1), 5807-5807 (2020-11-18)
Chronic nonalcoholic steatohepatitis (NASH) is a metabolic disorder that often leads to liver fibrosis, a condition with limited therapy options. Adiponectin is an adipocytokine that regulates glucose and lipid metabolism via binding to its receptors AdipoR1 and AdipoR2, and AdipoRs

Questions

  1. Good afternoon, I would like to know the solubility of compound JT003 for in vivo experiments on mice.  Thank you. Maria

    1 answer

    1. This product is not tested for in vivo or in vitro use. Several publication indicate that this compound has been used successfully in mouse models. Please see the links below to review publications that may be of interest.
      https://pubmed.ncbi.nlm.nih.gov/36873175/
      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7669869/

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