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S6883

Sigma-Aldrich

P 物质 乙酸盐 水合物

≥95% (HPLC), powder

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0.5 MG
$122.00
1 MG
$128.00
5 MG
$545.00
10 MG
$641.00
25 MG
$1,440.00

About This Item

经验公式（希尔记法）:
C63H98N18O13S · xC2H4O2 · yH2O
CAS号:
137348-11-9
分子量:
1347.63 (anhydrous free base basis)
Beilstein:
5153552
UNSPSC代码:
12352200
PubChem化学物质编号:
24899725
NACRES:
NA.32

$122.00

请联系客服了解存货情况
获取大包装报价

质量水平

200

方案

≥95% (HPLC)

表单

powder

分子量

1348 Da by calculation (Average Mass)

储存条件

(Keep container tightly closed in a dry and well-ventilated place.)

颜色

white

溶解性

0.1 M acetic acid: 1 mg/mL

UniProt登记号

P20366

储存温度

−20°C

SMILES字符串

[H]O[H].CC(O)=O.CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CCCCN)NC(=O)[C@@H]4CCCN4C(=O)[C@@H](N)CCCNC(N)=N)C(N)=O

InChI

1S/C63H98N18O13S.C2H4O2.H2O/c1-37(2)33-45(57(89)74-41(53(68)85)27-32-95-3)73-52(84)36-72-54(86)46(34-38-15-6-4-7-16-38)78-58(90)47(35-39-17-8-5-9-18-39)79-56(88)42(23-25-50(66)82)75-55(87)43(24-26-51(67)83)76-59(91)49-22-14-31-81(49)62(94)44(20-10-11-28-64)77-60(92)48-21-13-30-80(48)61(93)40(65)19-12-29-71-63(69)70;1-2(3)4;/h4-9,15-18,37,40-49H,10-14,19-36,64-65H2,1-3H3,(H2,66,82)(H2,67,83)(H2,68,85)(H,72,86)(H,73,84)(H,74,89)(H,75,87)(H,76,91)(H,77,92)(H,78,90)(H,79,88)(H4,69,70,71);1H3,(H,3,4);1H2/t40-,41-,42-,43-,44-,45-,46?,47-,48-,49-;;/m0../s1

InChI key

VHKFRLDSEZYWAC-CIYRQLMPSA-N

基因信息

human ... TAC1(6863)

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Amino Acid Sequence

Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2

一般描述

Research area: Cell Signaling

Substance P is a member of the tachykinin family of peptides.[1] It is encoded by the tachykinin precursor 1 (TAC1) gene mapped to human chromosome 7q21-q22. Substance P is a small peptide produced by macrophages, lymphocytes, eosinophils, dendritic cells and nerves. It is part of the neurokinin group.[2][3]

应用

Substance P acetate salt hydrate has been:

  • used as a neurokinin 1 (NK1) receptor agonist for the activation of spinal nociceptive circuitry in mice[4]
  • administered in central nucleus (ACE) in rat to study its positive reinforcing effects[5]
  • used in competition binding assays[6]
  • used as an inhibitor of myosin light chain kinase in isolated lymphatic vessels from rat[7]

生化/生理作用

NK-1 激动剂；强效血管扩张剂和抗高血压剂。
NK-1 激动剂；强效血管扩张剂和抗高血压剂；诱导唾液分泌；增加毛细血管通透性；诱导肥大细胞脱颗粒；感觉（疼痛）传入中的假定神经递质。
Substance P has proinflammatory effects on epithelial and immune cells. It has been associated with inflammatory diseases related to gastrointestinal and respiratory systems. Substance P modulates contractility of smooth muscles, transport of ions in the epithelium, vascular permeability and immune functions in the gut.[2]

抗体

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储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000437212
0000437212
0000341063
0000341063
0000397145

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G F Joos et al.
Allergy, 55(4), 321-337 (2000-04-27)
The sensory neuropeptides substance P (SP) and neurokinin A (NKA) are localized to sensory airway nerves, from which they can be released by a variety of stimuli, including allergen, ozone, or inflammatory mediators. Sensory nerves containing these peptides are relatively
D G Snijdelaar et al.
European journal of pain (London, England), 4(2), 121-135 (2000-08-25)
Substance P is considered to be an important neuropeptide in nociceptive processes. Although substance P was described more than 60 years ago, there is still controversy about its exact role in nociception. This article reviews the current knowledge about the
Tae-You Kim et al.
Cancer research, 66(15), 7490-7501 (2006-08-04)
Malignant glioma is the most common central nervous system tumor of adults and is associated with a significant degree of morbidity and mortality. Gliomas are highly invasive and respond poorly to conventional treatments. Gliomas, like other tumor types, arise from
Effects of intraplantar botulinum toxin-B on carrageenan-induced changes in nociception and spinal phosphorylation of GluA1 and Akt
Sikandar S, et al.
The European Journal of Neuroscience, 44(1), 1714-1722 (2016)
The associations of TAC1 gene polymorphisms with major depressive disorder
Won E, et al
Molecular & Cellular Toxicology, 129-136 (2019)
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Questions

1–2 of 2 Questions  

  1. Hi, I would like to buy substance P for my research in humans. In particular, I plan to administer 20-minute infusions (8 pmol/kg/min) in volunteers. Can you confirm that your product is suitable?

    1 answer

    1. S6883, Sigma-Aldrich Substance P acetate salt hydrate, is not to be used in/on humans for any purpose.

      Helpful?

  2. How should Substance P acetate salt hydrate, Product S6883, be dissolved?

    1 answer

    1. As mentioned in the 'PROPERTIES' section of the Product Detail Page, this product can be dissolved in
      0.1 M acetic acid: 1 mg/mL.

      Helpful?

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