SML2341
Nω-Propyl-L-Arginine hydrochloride
≥98% (HPLC)
别名:
L-NPA, N(ω)-Propyl-L-arginine, N(w)-Propyl-L-arginine, N-ω-Propyl-L-arginine, N-Omega-propyl-L-Arginine, N5-[Imino(propylamino)methyl]-L-ornithine, NG-Propyl-L-arginine, NPA, NPLA, Nomega-Propyl-L-Arginine, PLA, p-ARG
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所有图片(1)
About This Item
经验公式（希尔记法）:
C9H20N4O2 · xHCl
CAS号:
分子量:
216.28 (free base basis)
MDL號碼:
分類程式碼代碼:
12352209
价格与库存信息目前不能提供
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化驗
≥98% (HPLC)
形狀
film
儲存條件
desiccated
顏色
colorless
溶解度
H2O: 2 mg/mL, clear
儲存溫度
−20°C
SMILES 字串
CCCNC(NCCC[C@H](N)C(O)=O)=N
InChI
1S/C9H20N4O2/c1-2-5-12-9(11)13-6-3-4-7(10)8(14)15/h7H,2-6,10H2,1H3,(H,14,15)(H3,11,12,13)/t7-/m0/s1
InChI 密鑰
AOMXURITGZJPKB-ZETCQYMHSA-N
生化／生理作用
Nω-Propyl-L-arginine (NPA; NPLA; p-ARG; L-PNA) is a substrate-competitive, reversible, potent and selective neuronal nitric oxide synthase (nNOS; bNOS) inhibitor (Ki = 57 nM/bovine nNOS, 8.5 μM/bovine eNOS, 180 μM/murine iNOS) widely used for probing nNOS-dependent physiological and pathological processes both in cultures and in animals in vivo.
Substrate-competitive, reversible, potent and selective neuronal nitric oxide synthase (nNOS; bNOS) inhibitor with in vitro and in vivo efficacy.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Hui-Hsing Hung et al.
Molecular and cellular neurosciences, 82, 35-45 (2017-04-22)
Zinc ion (Zn2+), the second most abundant transition metal after iron in the body, is essential for neuronal activity and also induces toxicity if the concentration is abnormally high. Our previous results show that exposure of cultured cortical neurons to
Al Muktafi Sadi et al.
Clinical science (London, England : 1979), 132(6), 641-654 (2018-03-01)
Background: Heart failure (HF) is associated with reduced expression of plasma membrane Ca2+-ATPase 4 (PMCA4). Cardiac-specific overexpression of human PMCA4b in mice inhibited nNOS activity and reduced cardiac hypertrophy by inhibiting calcineurin. Here we examine temporally regulated cardiac-specific overexpression of
Potent and selective inhibition of neuronal nitric oxide synthase by N omega-propyl-L-arginine.
H Q Zhang et al.
Journal of medicinal chemistry, 40(24), 3869-3870 (1997-12-16)
Yiting Zhang et al.
Neurobiology of disease, 110, 122-132 (2017-12-06)
Germinal matrix hemorrhage is induced by stereotaxic injection of collagenase into the germinal matrix of P7 Sprague-Dawley rats. Hemoglobin assay, western blot, immunofluorescence and neurobehavioral tests were used to test the effects of BLVRA on hematoma resolution and anti-inflammatory response.
Qing-Bo Lu et al.
International journal of molecular sciences, 19(1), 59-59 (2017-12-28)
This study was conducted to explore the hypothesis that the endogenous superoxide anions (O₂-) and nitric oxide (NO) system of the paraventricular nucleus (PVN) regulates the cardiac sympathetic afferent reflex (CSAR) contributing to sympathoexcitation in obese rats induced by a
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