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生物源
human
重組細胞
expressed in E. coli
化驗
≥90% (HPLC)
形狀
solid
雜質
≤1 EU/μg
運輸包裝
wet ice
儲存溫度
−20°C
基因資訊
human ... AMELX(265)
一般說明
Research area: Neuroscience
Amelogenin, X isoform belongs to the family of closely related amelogenin proteins that participate in the amelogenesis process of teeth mineralization. Amelogenins account for more than 90% of the total protein in developing tooth enamel.
Amelogenin, X isoform belongs to the family of closely related amelogenin proteins that participate in the amelogenesis process of teeth mineralization. Amelogenins account for more than 90% of the total protein in developing tooth enamel.
生化／生理作用
Mutations in AMELX are responsible for the development of the rare disease Amelogenesis imperfecta 1E (AI1E), which is characterized by abnormal tooth enamel development. Amelogenins act both as attachment factors and as a growth factor for mesenchymal stem cells. Amelogenin is of increasing importance as a potential therapeutic agent for variety of application including treatment hard-to-heal wounds, promoting remineralization of caries lesions, and repairing human tooth enamel.
準備報告
The product can be reconstituted in water or 2% acetic acid in a concentration of 0.1-5 mg/ml. Tap vial to make sure protein is reconstituted. Aliquot reconstituted Amelogenin and store at -20 °C. Avoid repeated freeze/thaw cycles. Amelogenin may form thin clear film on some surfaces, leading to reduced concentration in solution. Exact Amelogenin concentration can be determined by absorption at 280nm. Amelogenin solution of 0.1% has A280=1.35
其他說明
The product is supplied as lyophilized powder, prepared from a 0.2 μM filtered solution of Amelogenin in 2% acetic acid without any additives. The lyophilized product is essentially salt free. The biological activity of recombinant, human AMELX is measured by its ability to promote attachment of Saos-2 cells to a coated surface. The ED50 is defined as the amount of AMELX per cm2 that elicits 50% of the maximal attachment activity.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Regeneration of bone and periodontal ligament induced by recombinant amelogenin after periodontitis.
Haze, A. et al.
Journal of Cellular and Molecular Medicine, 13(6), 1110-1124 (2009)
M Lagerström-Fermér et al.
Genomics, 26(1), 159-162 (1995-03-01)
Formation of tooth enamel is a poorly understood biological process. In this study we describe a 9-bp deletion in exon 2 of the amelogenin gene (AMGX) causing X-linked hypoplastic amelogenesis imperfecta, a disease characterized by defective enamel. The mutation results
Frank Schwarz et al.
Clinical oral investigations, 8(3), 165-171 (2004-04-03)
The purpose of the present study was to investigate the effects of an enamel matrix protein derivative (EMD) on attachment, proliferation, and viability of human SaOs(2) osteoblasts on titanium implants. A total of 220 sand-blasted and acid-etched (SLA) titanium discs
Masanobu Izumikawa et al.
TheScientificWorldJournal, 2012, 879731-879731 (2012-05-02)
The aim of this study was to clarify the function of amelogenin, the major protein of enamel matrix derivative, on the proliferation, differentiation, and mineralization of cultured rat bone marrow stem cells (BMSCs), toward the establishment of future bone regenerative
Maggie Zeichner-David et al.
European journal of oral sciences, 114 Suppl 1, 244-253 (2006-05-06)
Enamel proteins, particularly amelogenin, have been associated with other functions in addition to regulating enamel biomineralization. Extracts of enamel proteins are currently being used to regenerate periodontal tissues, and new studies suggest that enamel proteins might have chondrogenic and osteogenic
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