To thaw the product, it should be quickly thawed in a 37°C water bath and removed as soon as it is thawed. The product should then be stored at 2 – 8°C for up to one week, at -20°C for up to three months, and at -70°C for up to 24 months. For further dilutions, it should be diluted with 0.15 M sodium chloride.
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生化/生理作用
低密度脂蛋白（LDL）是一种脂蛋白，可通过血液循环将胆固醇运送至全身。LDL 的作用是将胆固醇转移到身体的组织和器官。俗称“有害胆固醇”，高水平的低密度脂蛋白可导致动脉斑块形成。
LDL 和 HDL 在血浆中运输膳食胆固醇和内源性胆固醇。LDL 是胆固醇和胆固醇酯的主要转运蛋白，占血浆总脂蛋白的一半以上。LDL 通过受体介导的内吞作用被肝脏和其他组织吸收。LDL 受体的胞质结构域促进包被的凹陷（膜的受体富集区）的形成。受体的配体结合结构域识别 LDL 上的 apo-B100，导致形成网格蛋白包被的囊泡。依赖 ATP 的质子泵降低了囊泡内的 pH，导致 LDL 从其受体解离。失去网格蛋白包被后，囊泡与溶酶体融合，进而导致肽和胆固醇酯酶水解。LDL 受体可以再循环至细胞膜。研究表明，胰岛素、三碘甲状腺氨酸和地塞米体与 LDL 受体介导的摄取的调节有关
LDL 和 HDL 在血浆中运输膳食胆固醇和内源性胆固醇。LDL 是胆固醇和胆固醇酯的主要转运蛋白，占血浆总脂蛋白的一半以上。LDL 通过受体介导的内吞作用被肝脏和其他组织吸收。LDL 受体的胞质结构域促进包被的凹陷（膜的受体富集区）的形成。受体的配体结合结构域识别 LDL 上的 apo-B100，导致形成网格蛋白包被的囊泡。依赖 ATP 的质子泵降低了囊泡内的 pH，导致 LDL 从其受体解离。失去网格蛋白包被后，囊泡与溶酶体融合，进而导致肽和胆固醇酯酶水解。LDL 受体可以再循环至细胞膜。研究表明，胰岛素、三碘甲状腺氨酸和地塞米体与 LDL 受体介导的摄取的调节有关
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储存分类代码
10 - Combustible liquids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
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When working with LDL (SAE0053), is it acceptable to store a working solution at 4°C if used within the same week for several treatments? Alternatively, can LDL go through freeze-thaw cycles?
1 answer-
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What is the difference between products SAE0053 and 437644 (both LDL from human plasma)? Can you provide more characetristics of SAE0053 product?
1 answer-
Regarding Product SAE0053, the volume and concentration are not fixed, the only certainty is that the total cholesterol content of one bottle is 10mg. The total LDL particle concentration (protein+cholesterol+other lipids) is not currently determined, but based on published literature it is expected to be approximately twice the cholesterol concentration.
Please see the link below for testing performed on this product:
https://www.sigmaaldrich.cn/specification-sheets/228/747/SAE0053-10MG______SIGMA____.pdf
Regarding Product 437644, a 10 mg vial contains ~2 mg of protein. This product is under the product line Calbiochem®. The formulation is 150 mM NaCl, 0.01% EDTA, pH 7.4. The source of this material is prepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.Please see the link below for testing performed on this product:
https://www.sigmaaldrich.com/specification-sheets/228/747/SAE0053-10MG______SIGMA____.pdfHelpful?
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