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Merck
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S5321

Sigma-Aldrich

S15535

≥98% (HPLC), solid

别名:

1-(2,3-Dihydro-1,4-benzodioxin-5-yl)-4-(2,3-dihydro-1h-inden-2-yl)-piperazine

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About This Item

经验公式（希尔记法）:
C21H24N2O2
CAS号:
146998-34-7
分子量:
336.43
MDL编号:
MFCD00911672
UNSPSC代码:
12352200
PubChem化学物质编号:
329824452
NACRES:
NA.77
价格与库存信息目前不能提供

方案

≥98% (HPLC)

表单

solid

颜色

white

溶解性

DMSO: ~6 mg/mL
H2O: insoluble

储存温度

2-8°C

SMILES字符串

C1COc2c(O1)cccc2N3CCN(CC3)C4Cc5ccccc5C4

InChI

1S/C21H24N2O2/c1-2-5-17-15-18(14-16(17)4-1)22-8-10-23(11-9-22)19-6-3-7-20-21(19)25-13-12-24-20/h1-7,18H,8-15H2

InChI key

QJPPEMXOOWNICQ-UHFFFAOYSA-N

应用

S15535 has been used as a serotonin 1A receptor (5-HT1A) agonist in zebrafish.[1]
S15535 may be used in histamine 5-HT1A-medaited cell signaling studies.

生化/生理作用

Potent, orally active, partial 5-HT1A receptor agonist
S15535, a benzodioxane, is a selective but partial agonist of histamine serotonin 1A (5-HT1A) receptor. It activates presynaptic 5-HT1A receptors and suppresses the release of hippocampal 5-HT. It acts as an anxiolytic agent and modulates the cholinergic and cognitive function in rodents.[2]

象形图

Environment
GHS09

警示用语：

Warning

危险声明

H410

预防措施声明

P273 - P391 - P501

危险分类

Aquatic Acute 1 - Aquatic Chronic 1

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
016K46151
017K4619
017K4609
016K4615

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M J Millan et al.
The Journal of pharmacology and experimental therapeutics, 282(1), 148-161 (1997-07-01)
In these studies, we characterized the influence of the novel benzodioxopiperazine serotonin (5-HT)1A ligand, S 15535, on the release of 5-HT in rat hippocampus and compared its potential anxiolytic properties with those of the 5-HT1A receptor partial agonist, buspirone, the
M J Millan et al.
The Journal of pharmacology and experimental therapeutics, 282(1), 132-147 (1997-07-01)
The novel, potential anxiolytic, S 15535 (4-(benzodioxan-5-yl)1-(indan-2-yl)piperazine), is an agonist and antagonist (weak partial agonist) at pre- and postsynaptic serotonin (5-HT)1A receptors, respectively. Herein, we characterized its influence on dialysate levels of 5-HT, dopamine (DA) and NAD simultaneously determined in
F Lejeune et al.
Synapse (New York, N.Y.), 30(2), 172-180 (1998-09-02)
This study examined the influence of the highly selective 5-HT1A receptor ligands, flesinoxan, S 15535, and WAY 100,635, upon the electrical activity of dopaminergic neurons in the ventral tegmental area (VTA), as compared to serotonergic neurons in the dorsal raphe
Jiun Youn et al.
Neuropharmacology, 57(5-6), 567-576 (2009-07-18)
5-HT(1A) receptors are implicated in the modulation of cognitive processes including encoding of fear learning. However, their exact role has remained unclear due to contrasting contributions of pre- vs. postsynaptic 5-HT(1A) receptors. Therefore, their role in fear conditioning was studied
R L Gannon et al.
Neuroscience, 137(1), 287-299 (2005-11-18)
Mammalian circadian activity rhythms are generated by pacemaker cells in the suprachiasmatic nucleus (SCN). As revealed by the actions of diverse agonists, serotonergic input from raphe nuclei generally inhibits photic signaling in the suprachiasmatic nucleus. In contrast, the serotonin (5HT)1A
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