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一般描述
Research area: Cell signaling. Glutathione Reductase belongs to the homodimericFAD−disulfide oxidoreductases family. is made up of highly conserved domains such as two Rossmann fold domains, where one binds to reduced nicotinamide adenine dinucleotide phosphate (NADPH) and flavin adenine dinucleotide (FAD) the second one is an interface dimerization domain. It favors its accumulation in the regions of high electron flux in cells where reactive species are generated.[1]
生化/生理作用
谷胱甘肽还原酶是一种同源二聚体酶，每个亚基含有 1 个 FAD 分子和 1 个 NADPH 结合域。 人 GR (hGR) 和 恶性疟原虫 GR (PfGR) 对于疟原虫在人红细胞内的生存是必需的。因此，这种酶可用于候选抗疟疾试剂的研究。
谷胱甘肽还原酶是一种普遍存在的黄酶，参与细胞应激的保护。谷胱甘肽还原酶催化氧化型谷胱甘肽 (GSSG) 还原成谷胱甘肽 (GSH)。对维持足够水平的还原型细胞 GSH（作为与自由基和有机过氧化物反应的抗氧化剂）的谷胱甘肽氧化还原循环至关重要。谷胱甘肽还是谷胱甘肽过氧化物酶的电子供体，也是谷胱甘肽 S-转移酶的底物，有助于解毒和消除有毒亲电代谢物和外源性物质。
Human glutathione reductase is suitable as cytostatic and antimalarialagent. It may also be used to protect against malaria by mimicking favism by blockingthe enzyme with specific inhibitors.
单位定义
在 pH 7.5、25°C 下 1 个单位将还原 1.0μmol DTNB/min
外形
含 25 mM Tris-HCl (pH 7.4)、1 mM EDTA 和 50% (v/v) 甘油的溶液。
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储存分类代码
10 - Combustible liquids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
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Cells in aerobic condition are constantly exposed to reactive oxygen species (ROS), which may induce damage to biomolecules, including proteins, nucleic acids and lipids. In normal circumstances, the amount of ROS is counterbalanced by cellular antioxidant defence, with its main
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