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Merck
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文件

C2506

Sigma-Aldrich

细胞色素 C 来源于马心脏

≥95% (SDS-PAGE)

别名:

Cytochrome c 来源于马心脏

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About This Item

CAS号:
9007-43-6
EC號碼:
232-700-9
MDL號碼:
MFCD00130890
分類程式碼代碼:
12352202
NACRES:
NA.61

生物源

horse heart

化驗

≥95% (SDS-PAGE)

形狀

powder

分子量

12,384

技術

cell based assay: suitable

溶解度

H2O: soluble 10 mg/mL

適合性

suitable for molecular biology

UniProt登錄號

P00004

應用

cell analysis

儲存溫度

−20°C

基因資訊

horse ... CYCS(100053958)

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應用

细胞色素c已用于：
  • 还原由黄嘌呤氧化酶生成的超氧自由基-铁氧化铬c
  • 采用MALDI质谱法，用单液滴沉积法进行分析
  • 作为标准细胞色素c还原酶活性测定的末端电子受体
  • 细胞色素c氧化酶组织化学
  • 用于细胞色素C氧化酶活性的测定
  • 作为磷酸盐缓冲液的组分，用于采用蓝色天然凝胶电泳 (BN-PAGE) 检测和评估复合物 IV 活性
  • 用于检测离体肾脏吞噬细胞中的细胞外超氧阴离子 (ECSA)
马的细胞色素c经过H2O2和UV 处理后的特异性位点和氧化程度已经过表征。研究表明这些位点可能可用作细胞内氧化环境的生物标记。

生化／生理作用

细胞色素 c 从线粒体外层释放到胞质溶胶中，有助于激活 caspase-9 并启动凋亡蛋白酶级联反应。其与凋亡蛋白酶激活因子-1 (APAF-1) 和三磷酸脱氧腺苷 (dATP) 的相互作用可促进这一过程。(3)各种研究表明，测定肿瘤患者血清中的细胞色素 C 水平可以被认为是体内细胞死亡的潜在标志。
细胞色素c的主要身份是电子载体线粒体蛋白。在细胞内，细胞色素c能够在二价铁和三价铁之间转化，使得它称为了有效的生物电子载体，在动植物细胞内氧化中起到很重要的作用。它通常被视作呼吸作用催化剂，在呼吸底物和氧气之间形成必需的电子桥

準備報告

Prepared using TCA.

其他說明

2024年CiteAb奖——成功的帕金森研究供应商(2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research)
想要了解更多细胞色素c和电子传递的信息，请访问www.sigma-aldrich.com/enzymeexplorer.

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

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?-1,3 glucan derived from Euglena gracilis and Algamune? enhances innate immune responses of red drum (Sciaenops ocellatus L.)
Yamamoto FY, et al.
Fish & Shellfish Immunology, 77, 273-279 (2018)
Rapid extracellular release of cytochrome c is specific for apoptosis and marks cell death in vivo
Renz A, et al.
Blood, 98(5), 1542-1548 (2001)
B C Hill
The Journal of biological chemistry, 266(4), 2219-2226 (1991-02-05)
The reaction of the electrostatic cytochrome c-cytochrome oxidase complex with oxygen is measured by transient absorption spectroscopy. The oxygen reaction is initiated by photolytic removal of CO from cytochrome oxidase, using a flash-pumped dye laser. The subsequent reaction of the
Enzyme-catalyzed free radical reactions with nicotinamide adenine nucleotides. II. Lactate dehydrogenase-catalyzed oxidation of reduced nicotinamide adenine dinucleotide by superoxide radicals generated by xanthine oxidase.
P C Chan et al.
The Journal of biological chemistry, 249(4), 1317-1319 (1974-02-25)
A novel role of the mitochondrial permeability transition pore in (-)-gossypol-induced mitochondrial dysfunction
Warnsmann V, et al.
Mechanisms of Ageing and Development, 170, 45-58 (2018)
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Chromatograms

application for HPLCapplication for HPLCapplication for HPLC

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