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生物来源
human
质量水平
重组
expressed in E. coli
表单
liquid
分子量
52 kDa by SDS-PAGE
技术
ELISA: suitable
UniProt登记号
储存温度
−70°C
基因信息
human ... TRIM21(6737)
一般描述
Research area: Cell Signaling
RO-52 (SSA), also called as tripartite motif-containing protein 21 (TRIM21) is a 52 kDa, ubiquitin E3 ligase.[1] It has a N-terminal RING finger domain (Really Interesting New Gene), crucial for ubiquitination functionality.[2] RO-52 (SSA) gene is mapped to human chromosome 11p5.5.
RO-52 (SSA), also called as tripartite motif-containing protein 21 (TRIM21) is a 52 kDa, ubiquitin E3 ligase.[1] It has a N-terminal RING finger domain (Really Interesting New Gene), crucial for ubiquitination functionality.[2] RO-52 (SSA) gene is mapped to human chromosome 11p5.5.
应用
生化/生理作用
RO-52 (SSA) is capable of autoubiquitination [7] and uniquitylates p62 protein and regulates redox homeostasis.[1]Patients with Sjogren′s syndrome display elevated levels of anti-Ro/SSA antibodies.[2] RO-52 levels in peripheral blood mononuclear cells (PBMC) contributes to pathogenesis of systemic lupus erythematosus (SLE)[8], systemic autoimmune rheumatic diseases (SARDs),[9] interstitial lung disease (ILD) and connective tissue diseases (CTD).[10] RO-52 is considered as potential target for treating SLE.[8]
Used for the detection and quantification of antibodies to RNPs in rheumatic diseases.
外形
solution contains 20 mM phosphate buffer, 500 mM NaCl, 2M - 3M urea, pH 6.
储存分类代码
10 - Combustible liquids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
TRIM21 ubiquitylates SQSTM1/p62 and suppresses protein sequestration to regulate redox homeostasis
Pan JA, et al.
Molecular Cell, 61(5), 720-733 (2016)
Accumulation of Antigen-Driven Lymphoproliferations in Complement Receptor 2/CD 21-/low B Cells From Patients With Sjogren's Syndrome
Glauzy S, et al.
Arthritis and Rheumatism, 70(2), 298-307 (2018)
New structural insights into the role of TROVE2 complexes in the on-set and pathogenesis of systemic lupus erythematosus determined by a combination of QCM-D and DPI
Juste-Dolz A, et al.
Analytical and Bioanalytical Chemistry, 1-12 (2018)
The Sjogren?s syndrome-associated autoantigen Ro52 is an E3 ligase that regulates proliferation and cell death
Espinosa A, et al.
Journal of Immunology, 176(10), 6277-6285 (2006)
Mapping molecular binding by means of conformational dynamics measurements
do Nascimento NM, et al.
Royal Society of Chemistry Advances, 8(2), 867-876 (2018)
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