推荐产品
product name
强的松, ≥98%
生物源
synthetic
無菌
non-sterile
化驗
≥98%
形狀
powder
mp
236-238 °C (lit.)
溶解度
chloroform/ethanol (1:1): 50 mg/mL, clear, colorless to light yellow
應用
hematology
運輸包裝
ambient
儲存溫度
room temp
SMILES 字串
O=C1C=C[C@@]2(C)C(CC[C@]([C@@](CC[C@@]3(C(CO)=O)O)([H])[C@]3(C)C4)([H])[C@]2([H])C4=O)=C1
InChI
1S/C21H26O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-15,18,22,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,18+,19-,20-,21-/m0/s1
InChI 密鑰
XOFYZVNMUHMLCC-ZPOLXVRWSA-N
基因資訊
human ... NR3C1(2908)
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應用
Prednisone has been used in dimethyl sulfoxide stock suspension to inject into experimental mice and to analyze the effects of glucocorticoid steroid. It has also been used as a test drug, formulated with peanut butter to study the effects of daily administration of MIDD0301, by animal weight, organ weight and haematological analysis.
生化／生理作用
Prednisone is a synthetic glucocorticoid with anti-inflammatory and immunosuppressive activity. It is useful in treating many disease states and has a half-life of 3.4 to 3.8 hours in plasma. Prednisone is metabolized to prednisolone, which is physiologically active.
特點和優勢
This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
訊號詞
Warning
危險聲明
危險分類
STOT RE 2
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
個人防護裝備
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
其他客户在看
Intermittent glucocorticoid dosing improves muscle repair and function in mice with limb-girdle muscular dystrophy
Quattrocelli M, et al.
The American Journal of Pathology, 187(11), 2520-2535 (2017)
Clinical pharmacokinetics of prednisone and prednisolone
Pickup ME
Clinical Pharmacokinetics, 4(2), 111-128 (1979)
MIDD 0301-A first-in-class anti-inflammatory asthma drug targets GABAA receptors without causing systemic immune suppression
Zahn NM, et al.
Basic and Clinical Pharmacology and Toxicology (2019)
Saunders Handbook of Veterinary Drugs - E-Book, 4(2), 645-645 (2010)
Gerard J Criner et al.
Chest, 147(4), 894-942 (2014-10-17)
COPD is a major cause of morbidity and mortality in the United States as well as throughout the rest of the world. An exacerbation of COPD (periodic escalations of symptoms of cough, dyspnea, and sputum production) is a major contributor
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