I7379

丙米嗪 盐酸盐

≥99% (TLC), powder, antidepressant

• 别名: 10,11-二氢-N，N-二甲基-5H-苯并[b，f]氮杂卓-5-丙胺 盐酸盐, 5-[3-(二甲基氨基)丙基]-10,11-二氢-5H-苯并[b，f] 氮杂卓 盐酸盐
• 经验公式（希尔记法）: C₁₉H₂₄N₂ · HCl
• CAS号: 113-52-0
• 分子量: 316.87
• EC號碼: 204-030-7
• MDL號碼: MFCD00012669
• 分類程式碼代碼: 12352116
• PubChem物質ID: 24278097
• NACRES: NA.77

属性

• product name: 丙米嗪 盐酸盐, ≥99% (TLC)
• 化驗: ≥99% (TLC)
• 形狀: powder
• 顏色: white
• 溶解度: H₂O: 50 mg/mL
• 起源: Novartis
• SMILES 字串: Cl[H].CN(C)CCCN1c2ccccc2CCc3ccccc13
• InChI: 1S/C19H24N2.ClH/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21;/h3-6,8-11H,7,12-15H2,1-2H3;1H
• InChI 密鑰: XZZXIYZZBJDEEP-UHFFFAOYSA-N
• 基因資訊: human ... HTR1A(3350) , HTR1B(3351) , HTR1D(3352) , HTR1E(3354) , HTR1F(3355) , HTR2A(3356) , HTR2B(3357) , HTR2C(3358) , HTR3A(3359) , HTR3B(9177) , HTR3C(170572) , HTR3D(200909) , HTR3E(285242) , HTR4(3360) , HTR5A(3361) , HTR5B(645694) , HTR6(3362) , HTR7(3363) , SLC6A2(6530) , SLC6A4(6532)

说明

一般說明

Imipramine is a tricyclic antidepressant. It has a half-life of 6 to 20 hours. Imipramine is made up of a tricyclic nucleus, that consists of two phenyl rings and a central cycloheptadien ring.

應用

Imipramine hydrochloride has been used:

• as a non- selective serotonin reuptake inhibitor (SSRI) tricyclic anti-depressant (DD-IMI) to treat animals
• to investigate its interaction with insulin in aqueous solution
• to abolish the ability of internalized lipoproteins to stimulate cholesteryl esterification

生化／生理作用

三环类抗抑郁药；抑制血清素和去甲肾上腺素转运蛋白的 K_i 值分别为 7.7 nM 和 67 nM。对多巴胺转运蛋白影响很小（K_i = 25 μM）。

特點和優勢

This compound is featured on the Biogenic Amine Transporters and Chloride Channels pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

安全信息

• 象形圖: GHS06
• 訊號詞: Danger
• 危險聲明: H300
• 防範說明: P264 - P270 - P301 + P310 - P405 - P501
• 危險分類: Acute Tox. 2 Oral
• 儲存類別代碼: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable