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无菌性
sterile-filtered
质量水平
表单
lyophilized powder
包装
vial of 50 μg toxin (Also contains 10 mM Tris, 0.1 M NaCl, and 0.1% sucrose, pH 8.3.)
储存温度
−20°C
生化/生理作用
Pasteurella multocida toxin (PMT) is a bacterial protein toxin produced by few P. multocida serotype A and D strains. It acts as an effective mitogen in numerous cell types in vitro.[1] PMT inhibits osteoblast differentiation by activating the Rho/Rho-associated coiled-coil containing protein kinase (Rho/ROCK) pathway.[2] Infections of PMT cause atrophic rhinitis in pigs and by local dermatonecrosis, respiratory disease in cattle and rabbits. PMT is also a pathogenic agent of dermatonecrosis and bacteremia in humans.[3]
特点和优势
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储存分类代码
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
The Pasteurella multocida toxin is encoded within a lysogenic bacteriophage
Pullinger GD, et al.
Molecular Microbiology, 51(1), 255-269 (2004)
Pleiotropic effects of Pasteurella multocida toxin are mediated by Gq-dependent and-independent mechanisms involvement of Gq but not G11
Zywietz A, et al.
The Journal of biological chemistry, 276(6) (2001)
Regulation of osteoblast differentiation by Pasteurella multocida toxin (PMT): a role for Rho GTPase in bone formation
Harmey D, et al.
Journal of Bone and Mineral Research, 19(4), 661-670 (2004)
商品
Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
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