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Merck

P5084

Sigma-Aldrich

PTIO

别名:

2-苯基-4,4,5,5-四甲基咪唑啉-1-氧代 3-氧化物

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25 MG
$293.00
100 MG
$791.00

About This Item

经验公式(希尔记法):
C13H17N2O2
CAS号:
分子量:
233.29
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.32

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表单

powder

质量水平

储存温度

2-8°C

SMILES字符串

CC1(C)N([O])C(c2ccccc2)=[N+]([O-])C1(C)C

InChI

1S/C13H17N2O2/c1-12(2)13(3,4)15(17)11(14(12)16)10-8-6-5-7-9-10/h5-9H,1-4H3

InChI key

DYUUGILMVYJEHY-UHFFFAOYSA-N

应用

2-苯基-4,4,5,5,-四甲基咪唑啉-1-氧代 3-氧化物 (PTIO) 已被用作一氧化氮 (NO) 清除剂。[1][2]

生化/生理作用

2-苯基-4, 4, 5, 5-四甲基咪唑-1-氧代 3-氧化物 (PTIOs) 衍生物与一氧化氮 (NO) 反应生成相应的的亚氨基氮氧化物 (PTIs) 和二氧化氮 (NO2)。[3]
一种稳定的一氧化氮自由基清除剂;不影响 NO 合成酶而影响 NO;对无生物活性有显著抑制活性。
稳定的一氧化氮自由基清除剂,不影响 NO 合成酶;抑制 NO 活性。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Victoria P A Johnstone et al.
Learning & memory (Cold Spring Harbor, N.Y.), 18(10), 625-633 (2011-09-22)
Long-term potentiation (LTP) is an important process underlying learning and memory in the brain. At CA3-CA1 synapses in the hippocampus, three discrete forms of LTP (LTP1, 2, and 3) can be differentiated on the basis of maintenance and induction mechanisms.
Ekaterina Minaeva et al.
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Truncated hemoglobins constitute a large family, present in bacteria, in archaea and in eukaryotes. However, a majority of physiological functions of these proteins remains to be elucidated. Identification and characterization of a novel role of truncated hemoglobins in the model
Moonhee Lee et al.
Brain research, 1400, 99-111 (2011-06-07)
Activated monocytes/macrophages are known to release toxic materials. Identification of these materials is important for developing more effective treatments for inflammatory disorders where self attack occurs. We stimulated human monocytes and THP-1 cells with LPS/IFNγ and measured the toxic effects
Nitric oxide is involved in methyl jasmonate-induced defense responses and secondary metabolism activities of Taxus cells.
Wang JW and Wu JY
Plant & Cell Physiology, 46(6), 923-930 (2005)
Luca G Mariotti et al.
International journal of radiation biology, 88(10), 751-762 (2012-06-20)
To investigate the mechanisms regulating the pathways of the bystander transmission in vitro, focusing on the radiation-perturbed signalling (via Interleukine 6, IL-6) of the irradiated cells after exposure to low doses of different radiation types. An integrated 'systems radiation biology'

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