所有图片(2)
About This Item
经验公式（希尔记法）:
C10H16N4O7S
CAS号:
分子量:
336.32
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.32
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品質等級
化驗
≥97%
形狀
powder
溶解度
water: soluble 19.60-20.40 mg/mL
儲存溫度
−20°C
SMILES 字串
N[C@@H](CCC(=O)N[C@@H](CSN=O)C(=O)NCC(O)=O)C(O)=O
InChI
1S/C10H16N4O7S/c11-5(10(19)20)1-2-7(15)13-6(4-22-14-21)9(18)12-3-8(16)17/h5-6H,1-4,11H2,(H,12,18)(H,13,15)(H,16,17)(H,19,20)/t5-,6-/m0/s1
InChI 密鑰
HYHSBSXUHZOYLX-WDSKDSINSA-N
一般說明
S-亚硝基谷胱甘肽（GSNO）是一种内源性氮氧化物，在肺和脑的细胞外液中高表达。
應用
S-亚硝基谷胱甘肽（GSNO）已用作：
- 作为反相色谱的标准品，与化学蒸汽发生和原子荧光检测器（RPC-CVGAFS）和反相色谱荧光（RPC-FD）相结合。
- 作为分光光度法和高效液相色谱（HPLC）测定的标准品。
生化／生理作用
S-亚硝基谷胱甘肽（GSNO）抑制兔骨骼肌中肌浆网结合肌酸激酶的活性，并最终减少肌浆网囊泡中 ATP 驱动的 Ca2+ 摄取。气道细胞中的 GSNO 使气道平滑肌松弛并增强气道纤毛运动。它还阻断气道上皮阿米洛利敏感的钠转运，同时刺激钙依赖性上皮细胞氯转运并诱导中性粒细胞凋亡。此外，它还具有抗菌活性。囊性纤维化（CF）气道中 GSNO 浓度低。它是NO供体，可作为平滑肌松弛剂和血管扩张剂，并且能抑制体内的血小板活化。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
Inhibition of creatine kinase by S-nitrosoglutathione.
Wolosker H
Febs Letters, 392(3), 274-276 (1996)
C A Staab et al.
Cellular and molecular life sciences : CMLS, 65(24), 3950-3960 (2008-11-18)
Alcohol dehydrogenase 3 (ADH3) is highly conserved, ubiquitously expressed in mammals and involved in essential cellular pathways. A large active site pocket entails special substrate specificities: shortchain alcohols are poor substrates, while medium-chain alcohols and particularly the glutathione adducts S-hydroxymethylglutathione
C C Chiueh et al.
Free radical research, 31(6), 641-650 (2000-01-12)
Recent results demonstrated that S-nitrosoglutathione (GSNO) and nitric oxide (*NO) protect brain dopamine neurons from hydroxyl radical (*OH)-induced oxidative stress in vivo because they are potent antioxidants. GSNO and *NO terminate oxidant stress in the brain by (i) inhibiting iron-stimulated
Benjamin Gaston et al.
American journal of respiratory and critical care medicine, 173(11), 1186-1193 (2006-03-11)
Genetic and biochemical data demonstrate a pivotal role for S-nitrosothiols (SNOs) in mediating the actions of nitric oxide synthases (NOSs). SNOs serve to convey NO bioactivity and to regulate protein function. This understanding is of immediate interest to the pulmonary
Emilia Bramanti et al.
Talanta, 81(4-5), 1295-1299 (2010-05-06)
In this work we compared the results of the GSNO determination in human plasma by two independent methods. The first method is based on the pre-column derivatization of GSNO thiolic part by p-hydroxymercury benzoate (PHMB) and followed by the determination
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