P2076

Polymyxin B nonapeptide hydrochloride

lyopholized powder

• 别名: PMBN
• 经验公式（希尔记法）: C₄₃H₇₄N₁₄O₁₁ · xHCl
• 分子量: 963.13 (free base basis)
• MDL编号: MFCD00214217
• UNSPSC代码: 12352209
• PubChem化学物质编号: 24898270
• NACRES: NA.26

属性

• 产品名称: Polymyxin B nonapeptide hydrochloride, cationic cyclic peptide
• 质量水平: 200
• 表单: lyophilized powder
• 颜色: white to light yellow
• 应用: cell analysis
• 储存温度: 2-8°C
• SMILES字符串: CC(C)CC1NC(=O)C(Cc2ccccc2)NC(=O)C(CCN)NC(=O)C(CCNC(=O)C(NC(=O)C(CCN)NC(=O)C(CCN)NC1=O)C(C)O)NC(=O)C(CCN)NC(=O)C(N)C(C)O
• InChI: 1S/C43H74N14O11/c1-22(2)20-31-40(65)52-26(10-15-44)35(60)51-29(13-18-47)39(64)57-34(24(4)59)43(68)49-19-14-30(53-36(61)28(12-17-46)54-42(67)33(48)23(3)58)38(63)50-27(11-16-45)37(62)56-32(41(66)55-31)21-25-8-6-5-7-9-25/h5-9,22-24,26-34,58-59H,10-21,44-48H2,1-4H3,(H,49,68)(H,50,63)(H,51,60)(H,52,65)(H,53,61)(H,54,67)(H,55,66)(H,56,62)(H,57,64)
• InChI key: PYHYGIPVYYRJHU-UHFFFAOYSA-N

说明

应用

Polymyxin B nonapeptide hydrochloride has been used as an outer membrane permeabilizer, to characterize PAßN activity on membrane.[1] It has been used as a control in antibacterial assays.[2]

生化/生理作用

PMBN has endotoxin-neutralizing activity and thus can be utilized in adjunctive therapy against Gram-negative sepsis. It has been found that PMBN is less toxic than polymyxin B. Unlike polymyxin B, PMBN does not exhibit neurotoxicity and nephrotoxicity. While it retains the anti endotoxin property of the parent compound, it is much less potent.[3]

Polymyxin B nonapeptide (PMBN), a cationic cyclic peptide derived from the antibacterial peptide polymyxin B, specifically increases the permeability of the outer membrane of Gram-negative bacteria toward hydrophobic antibiotics.[4][5][6] PMBN has been used to evaluate multidrug efflux inhibitors in E. coli.[7]

Polymyxin B nonapeptide hydrochloride is a derivative of PMB that induces outer membrane permeability in gram-negative bacteria.

安全信息

• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable
• 个人防护装备: Eyeshields, Gloves, type N95 (US)