The product specification does not include a base pair length, and it is not determined in quality control testing. The best estimate is that the polymer is a mixture of different lengths ranging from 150 base pairs to 2,000 base pairs. Users requiring more specificity of the base pair lengths may need to determine it using gel electrophoresis.
推荐产品
质量水平
表单
powder
储存温度
−20°C
SMILES字符串
[P](=O)(OC[C@H]3O[C@H]([C@@H]([C@@H]3O)O)[n]4c5ncnc(c5nc4)N)(O)O.[P](=O)(OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)N2C=CC(=O)NC2=O)(O)O
InChI
1S/C10H14N5O7P.C9H13N2O9P/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20;12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20);1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/t4-,6-,7-,10-;4-,6-,7-,8-/m11/s1
InChI key
VGQHQOKIMNKUEF-ZLOOHWKQSA-N
应用
聚腺苷酸-聚尿苷酸（polyAU）是一种双链同型二聚体，具有潜在的治疗活性，尤其是与放射疗法结合使用时。PolyA/U与其他双链和单链聚合物（如poly-A和poly-U）一起用于比较生理化学研究。
其他说明
双链均聚物
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
A Laplanche et al.
Breast cancer research and treatment, 64(2), 189-191 (2001-02-24)
With a median follow-up of 14 years, the combination of polyadenylic-polyuridylic acid plus locoregional radiotherapy (257 patients) has significantly improved disease-free survival (p = 0.03) and significantly reduced the incidence of metastases (p = 0.04) when compared to CMF alone
Polyadenylic acid-polyuridylic acid (poly A : U) and experimental murine brucellosis. II. Macrophages as target cells of poly A : U in experimental brucellosis.
E D Madraso et al.
Immunology, 35(1), 77-84 (1978-07-01)
Nathan W Luedtke et al.
Biochemistry, 42(39), 11391-11403 (2003-10-01)
Semisynthetic aminoglycoside derivatives may provide a means to selectively target viral RNA sites, including the HIV-1 Rev response element (RRE). The design, synthesis, and evaluation of derivatives based upon neomycin B, kanamycin A, and tobramycin conjugates of 9-aminoacridine are presented.
A A Ghazaryan et al.
Journal of biomolecular structure & dynamics, 24(1), 67-74 (2006-06-20)
We employed UV light absorption and circular dichroism (CD) spectroscopic measurements to study the binding of novel water-soluble porphyrins meso-tetra-(4N-allylpyridyl)porphyrin [TAlPyP4], and its Ag containing derivative to the poly(rA)poly(rU) and poly(rI)poly(rC) RNA duplexes. Our results suggest that TAlPyP4 associate with
Ivan Perrot et al.
Journal of immunology (Baltimore, Md. : 1950), 185(4), 2080-2088 (2010-07-20)
Cross-talk between NK cells and dendritic cells (DCs) is critical for the potent therapeutic response to dsRNA, but the receptors involved remained controversial. We show in this paper that two dsRNAs, polyadenylic-polyuridylic acid and polyinosinic-polycytidylic acid [poly(I:C)], similarly engaged human
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What is the average base pair length for this product
1 answer-
Helpful?
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I'd like to know the homogeneity of this product, or at least the % A:U base pairing. My application is sensitive to high mismatch and single strand RNA content and I'm hoping this is at least 85% A:U base paired.
1 answer-
Unfortunately, the homogeneity and A:U ratio are not determined for this product. The material is prepared by separately preparing polyA and polyU strands by an enzymatic method. The individual polyA and polyU strands are purified to remove low molecular weight species then annealed by heating, followed by a slow cooling process. Historical information indicates an approximate starting ratio of 1:2 molar concentration of Poly(A) to Poly(U), respectively. There is an estimated sodium content of 5 - 6%.
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