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Merck

P9528

Sigma-Aldrich

聚尿苷酸 钾盐

别名:

聚(U) 钾盐

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About This Item

CAS号:
MDL號碼:
分類程式碼代碼:
41106305
NACRES:
NA.51

化驗

≥98% (TLC)

品質等級

形狀

lyophilized powder

溶解度

water: 19.60-20.40 mg/mL, clear to slightly hazy, colorless

儲存溫度

−20°C

InChI

1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1

InChI 密鑰

DJJCXFVJDGTHFX-XVFCMESISA-N

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應用

聚尿苷酸(Poly(U))是一种尿苷的均聚物,常作为单链RNA模型化合物用于与其他ssRNA模型寡核苷酸如Poly(I)和Poly(C)相比较,以研究依赖于ssRNA调节如Toll样受体调节的过程。Poly(U)已被用作TLR7的一种有效激动剂。

準備報告

用多核苷酸磷酸化酶从UDP制备而得。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Soren Nielsen et al.
Science (New York, N.Y.), 340(6140), 1577-1580 (2013-07-03)
Gene expression in organisms involves many factors and is tightly controlled. Although much is known about the initial phase of transcription by RNA polymerase III (Pol III), the enzyme that synthesizes the majority of RNA molecules in eukaryotic cells, termination
Tiago Antonio de Souza et al.
PloS one, 7(2), e32305-e32305 (2012-03-03)
Plant pathogenic bacteria utilize an array of effector proteins to cause disease. Among them, transcriptional activator-like (TAL) effectors are unusual in the sense that they modulate transcription in the host. Although target genes and DNA specificity of TAL effectors have
A Maxwell Burroughs et al.
Nucleic acids research, 40(4), 1424-1437 (2011-11-08)
Recent research hints at an underappreciated complexity in pre-miRNA processing and regulation. Global profiling of pre-miRNA and its potential to increase understanding of the pre-miRNA landscape is impeded by overlap with highly expressed classes of other non coding (nc) RNA.
Liam M Longo et al.
Proceedings of the National Academy of Sciences of the United States of America, 117(27), 15731-15739 (2020-06-21)
De novo emergence demands a transition from disordered polypeptides into structured proteins with well-defined functions. However, can polypeptides confer functions of evolutionary relevance, and how might such polypeptides evolve into modern proteins? The earliest proteins present an even greater challenge
Hironori Otaka et al.
Proceedings of the National Academy of Sciences of the United States of America, 108(32), 13059-13064 (2011-07-27)
Major bacterial small RNAs (sRNAs) regulate the translation and stability of target mRNAs through base pairing with the help of the RNA chaperone Hfq. The Hfq-dependent sRNAs consist of three basic elements, mRNA base-pairing region, Hfq-binding site, and rho-independent terminator.

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