O8137

Osteoprotegerin/Fc Chimera from mouse

>95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder

• 别名: OCIF, OPG
• MDL编号: MFCD01867131
• UNSPSC代码: 12352202
• PubChem化学物质编号: 24898055
• NACRES: NA.32

属性

• 生物来源: mouse
• 质量水平: 200
• 重组: expressed in NSO cells
• 方案: >95% (SDS-PAGE)
• 表单: lyophilized powder
• 效能: 25-50 ng/mL ED₅₀
• 分子量: 100 kDa by SDS-PAGE (reducing); calculated mol wt 70.9 kDa
• 包装: pkg of 100 μg
• 杂质: endotoxin, tested
• UniProt登记号: O08712
• 储存温度: −20°C
• SMILES字符串: CCCCCCCCCCC#CCCCCCC(O)=O
• InChI: 1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h2-10,13-17H2,1H3,(H,19,20)
• InChI key: XXUPLYBCNPLTIW-UHFFFAOYSA-N
• 基因信息: mouse ... Tnfrsf11b(18383)

说明

一般描述

Osteoprotegerin (OPG) is a member of the TNFR (tumor necrosis factor receptor) superfamily that can act as a decoy receptor for RANKL (receptor activator of nuclear factor κ-B ligand) and TRAIL (tumor necrosis factor-related apoptosis-inducing ligand).[1][2] The primary structure of OPG protein consists of seven distinct domains, four of which corresponds to the extracellular cysteine-rich domains of TNFR proteins and constitutes the soluble OPG. OPG is expressed in a wide variety of tissues including adult heart, lung, kidney and liver. It is secreted both as a monomeric and a dimeric protein.[3]

生化/生理作用

Binding of soluble osteoprotegerin (OPG) to sRANKL (soluble receptor activator of nuclear factor κ-B ligand) inhibits osteoclastogenesis by interrupting the signaling between stromal cells and osteoclastic progenitor cells, thereby leading to excess accumulation of bone and cartilage.[1] Changes in the level of serum OPG are associated with atherosclerosis and cardiovascular disorders.[2] It might also be associated with malignancy and plays a regulatory role in multiple myeloma, prostate, breast, bladder and gastric carcinoma.[4] OPG plays a vital role in bone metabolism and is involved in inhibition of ovariectomy-associated bone loss in rats.[3][4]

OPG is a soluble secreted member of the tumor necrosis factor receptor superfamily that lacks any apparent cell-association motifs. It regulates the formation of osteoclasts and is involved in the regulation of bone resorption and remodeling. Human and mouse OPG share approximately 84% and 94% amino acid sequence identity, respectively, with rat OPG.

Soluble secreted member of the tumor necrosis factor receptor superfamily that lacks any apparent cell-association motifs; regulates the formation of osteoclasts and is involved in the regulation of bone resorption and remodeling.

外形

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.

分析说明

The biological activity is measured by its ability to neutralize apoptosis of mouse L-929 cells treated with 50 ng/ml recombinant human TRAIL.

安全信息

• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable